Cover for RNA Therapeutics

RNA Therapeutics

The Evolving Landscape of RNA Therapeutics

Book2022

Edited by:

Paloma H. Giangrande, Vittorio de Franciscis and John J. Rossi

RNA Therapeutics

The Evolving Landscape of RNA Therapeutics

Book2022

 

Cover for RNA Therapeutics

Edited by:

Paloma H. Giangrande, Vittorio de Franciscis and John J. Rossi

About the book

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Book description

RNA Therapeutics: The Evolving Landscape of RNA Therapeutics provides a comprehensive overview of RNA therapeutic modalities, from bench-to-bedside, with an emphasis on the increas ... read full description

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    Index

    Pages 451-456

About the book

Description

RNA Therapeutics: The Evolving Landscape of RNA Therapeutics provides a comprehensive overview of RNA therapeutic modalities, from bench-to-bedside, with an emphasis on the increasingly impactful areas of gene therapy, oligonucleotide therapeutics, gene editing and delivery. International leaders in the field examine RNA-based therapeutics tools that have been developed to-date to modulate cellular processes such as transcription, translation and protein function. Approved RNA-based therapies and lessons learned from failed therapies are discussed in-depth, as are evolving advances in RNA biochemical analysis, and similar advances that are enabling clinical application of RNA-based therapies.

Later sections discuss delivery technologies, remaining hurdles in research and translation, the therapy development process from the lab to the clinic, and novel RNA-based therapies currently in development.

RNA Therapeutics: The Evolving Landscape of RNA Therapeutics provides a comprehensive overview of RNA therapeutic modalities, from bench-to-bedside, with an emphasis on the increasingly impactful areas of gene therapy, oligonucleotide therapeutics, gene editing and delivery. International leaders in the field examine RNA-based therapeutics tools that have been developed to-date to modulate cellular processes such as transcription, translation and protein function. Approved RNA-based therapies and lessons learned from failed therapies are discussed in-depth, as are evolving advances in RNA biochemical analysis, and similar advances that are enabling clinical application of RNA-based therapies.

Later sections discuss delivery technologies, remaining hurdles in research and translation, the therapy development process from the lab to the clinic, and novel RNA-based therapies currently in development.

Key Features

  • Features leading experts in the field of RNA therapeutics, spanning all classes of RNA therapies
  • Provides a detailed examination of approved RNA therapies and lessons learned from failed therapeutics
  • Covers all aspects of therapeutic discovery and preclinical development, as well as clinical translation, manufacturing and regulatory aspects
  • Features leading experts in the field of RNA therapeutics, spanning all classes of RNA therapies
  • Provides a detailed examination of approved RNA therapies and lessons learned from failed therapeutics
  • Covers all aspects of therapeutic discovery and preclinical development, as well as clinical translation, manufacturing and regulatory aspects

Details

ISBN

978-0-12-821595-1

Language

English

Published

2022

Copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Imprint

Academic Press

Editors

Paloma H. Giangrande

Adjunct Associate Professor of Internal Medicine, University of Iowa, Iowa City, IA, United States

Vice President of Platform Discovery Sciences, Biology, Wave Life Sciences, Cambridge, MA, United States

Vittorio de Franciscis

Senior Collaborator, National Research Council (CNR), Institute of Genetic and Biomedical Research (IRGB)—UOS Milan Via Rita Levi Montalcini, Pieve Emanuele (MI), Italy

John J. Rossi

Professor and Chairman, Department of Molecular and Cellular Biology, Beckman Research Institute of the City of Hope Monrovia Biomedical Research Center, Monrovia, CA, USA