Chronic Obstructive Pulmonary Disease

1. Front Matter

   Pages i-xi

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2. Definition and Epidemiology

   1. Front Matter

      Pages 1-1

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   2. Definition of Chronic Obstructive Pulmonary Disease (COPD): Is the Latest GOLD Classification of Severity Still Valid?

      • Kazuhisa Asai, Kazuto Hirata

      Pages 3-16

   3. Epidemiology of COPD: Why Is the Disease So Poorly Recognized?

      • Yoko Shibata

      Pages 17-28

3. Genetic Predisposition and Pathogenic Mechanisms

   1. Front Matter

      Pages 29-29

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   2. Genetic Predisposition to COPD: Are There Any Relevant Genes Determining the Susceptibility to Smoking?

      • Takeo Ishii, Koichi Hagiwara

      Pages 31-55

   3. Pathogenesis of COPD (Persistence of Airway Inflammation): Why Does Airway Inflammation Persist After Cessation of Smoking?

      • Akane Kato, Masayuki Hanaoka

      Pages 57-72

   4. Pathogenesis of COPD 3: Oxidative Stress – Is There a Possibility of Developing New Drugs from the Standpoint of This Pathogenetic Mechanism?

      • Tadashi Sato, Kuniaki Seyama

      Pages 73-93

   5. Pathogenesis of COPD 4 – Cell Death, Senescence, and Autophagy: Is There a Possibility of Developing New Drugs from the Standpoint of This Pathogenetic Mechanism?

      • Kazuyoshi Kuwano, Jun Araya, Hiromichi Hara, Shunsuke Minagawa, Naoki Takasaka, Saburo Ito et al.

      Pages 95-111

4. Comorbidities

   1. Front Matter

      Pages 113-113

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   2. Pathogenesis of Comorbidities in COPD: By What Mechanism Does Long-Term Smoking Cause Systemic Inflammation?

      • Yuko Morishima, Nobuyuki Hizawa

      Pages 115-133

   3. Assessment of Inflammation in COPD: Are There any Biomarkers that Can be Used to Assess Pulmonary and Systemic Inflammation?

      • Nobuyuki Horita, Takeshi Kaneko

      Pages 135-158

5. Management and Treatment

   1. Front Matter

      Pages 159-159

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   2. Exercise Therapy for COPD: How Is Exercise Therapy Significant?

      • Takashi Motegi

      Pages 161-178

   3. Nutritional Therapy for COPD: What Is the Present State of Nutritional Therapy and Is There a Possibility of Developing New Drugs?

      • Takao Tsuji

      Pages 179-194

   4. Long-Term Oxygen Therapy (or Home Oxygen Therapy) for COPD: The Present State and Future Problems

      • Keisaku Fujimoto

      Pages 195-210

   5. Bronchodilators for COPD: At What Stage Should Therapeutic Intervention Be Initiated?

      • Takashige Kuraki

      Pages 211-243

   6. Inhaled Corticosteroids for COPD: Are Inhaled Corticosteroids Required in the Management of COPD?

      • Masayuki Itoh

      Pages 245-266

   7. New Anti-inflammatory Drugs for COPD: Is There a Possibility of Developing Drugs That Can Fundamentally Suppress Inflammation?

      • Yasuhiro Yamauchi, Takahide Nagase

      Pages 267-278

   8. Exacerbation of COPD: Why Do Exacerbations of COPD Attract Attention? Are There Any Preventive Methods?

      • Masamichi Mineshita

      Pages 279-295

This book considers chronic obstructive pulmonary disease (COPD) not as a simple inflammation of the lung but as a systemic inflammatory disease. Beginning with epidemiological studies, etiology, diagnosis and treatment, it elaborates further, illustrating some comorbidities and associations with other respiratory diseases. As such it provides numerous improved and more comprehensive treatment methods, including drug therapies as well as some non-drug therapies.  There are also chapters describing the pathogenesis, genetic abnormalities and newly discovered pathogenetic mechanisms that are expected to be studied further in the future.

Edited and written by pioneering researchers, each chapter summarizes the latest trends, describes future prospects and explores the unresolved and critical questions. Chronic Obstructive Pulmonary Disease - A Systemic Inflammatory Disease is a valuable resource to beginning researchers, physicians engaged in clinical practice, supervisors, and basic researchers whose work includes COPD.

• COPD
• Smoking
• Systemic Inflammation
• Protease
• Anti-Protease
• Exercise Therapy
• Nutritional Therapy
• Home Oxygen Therapy
• Asthma
• CPFE
• Combined Pulmonary Fibrosis and Emphysema
• Lung Cancer

“This is a well-written book that provides an elaborate overview of the current state of understanding about COPD and its genetics, pathogenesis, diagnosis, and treatment as well as comorbid disease conditions. As such, this book should be an essential addition for practicing pulmonologists and researchers working in the field of COPD.” (Santosh Dhungana, Doody’s Book Reviews, June, 2017)

• Department of Respiratory Medicine, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan

  Hiroyuki Nakamura, Kazutetsu Aoshiba

Editors

Hiroyuki Nakamura
Department of Respiratory Medicine
Tokyo Medical University Ibaraki Medical Center
Ibaraki, Japan

Kazutetsu Aoshiba
Department of Respiratory Medicine
Tokyo Medical University Ibaraki Medical Center
Ibaraki, Japan
 

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