Overview
- Comprehensively reviews the chemical, regulatory, and physiological mechanisms of protein arginine and lysine methyltransferases
- Highlights clinical applications of epigenetic editing in cancer treatment and aging
- Highlights hot topics such as cellular plasticity, novel biomarkers and genome-wide association studies
Part of the book series: RNA Technologies (RNATECHN)
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Table of contents (24 chapters)
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Front Matter
Keywords
About this book
This book reviews the chemical, regulatory, and physiological mechanisms of protein arginine and lysine methyltransferases, as well as nucleic acid methylations and methylating enzymes. Protein and nucleic acid methylation play key and diverse roles in cellular signalling and regulating macromolecular cell functions.
Protein arginine and lysine methyltransferases are the predominant enzymes that catalyse S-adenosylmethionine (SAM)-dependent methylation of protein substrates. These enzymes catalyse a nucleophilic substitution of a methyl group to an arginine or lysine side chain nitrogen (N) atom. Cells also have additional protein methyltransferases, which target other amino acids in peptidyl side chains or N-termini and C-termini, such as glutamate, glutamine, and histidine. All these protein methyltransferases use a similar mechanism. In contrast, nucleic acids (DNA and RNA) are substrates for methylating enzymes, which employ various chemical mechanisms to methylatenucleosides at nitrogen (N), oxygen (O), and carbon (C) atoms.
This book illustrates how, thanks to there ability to expand their repertoire of functions to the modified substrates, protein and nucleic acid methylation processes play a key role in cells.
Editors and Affiliations
About the editors
Prof. Dr. hab. Stefan Jurga,
Adam Mickiewicz University, Nanobiomedical Center,
Poznań, Poland
stjurga@amu.edu.pl
Prof. Dr.hab Jan Barciszewski,Institute of Bioorganic Chemistry of the Polish Academy of Sciences, Poznań, Poland and
Adam Mickiewicz University, Nanobiomedical Center, Poznań, Poland
jan.barciszewski@ibch.poznan.pl
Bibliographic Information
Book Title: The DNA, RNA, and Histone Methylomes
Editors: Stefan Jurga, Jan Barciszewski
Series Title: RNA Technologies
DOI: https://doi.org/10.1007/978-3-030-14792-1
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Switzerland AG 2019
Hardcover ISBN: 978-3-030-14791-4Published: 11 September 2019
Softcover ISBN: 978-3-030-14794-5Published: 11 September 2020
eBook ISBN: 978-3-030-14792-1Published: 28 August 2019
Series ISSN: 2197-9731
Series E-ISSN: 2197-9758
Edition Number: 1
Number of Pages: XI, 624
Number of Illustrations: 21 b/w illustrations, 57 illustrations in colour
Topics: Human Genetics, Nucleic Acid Chemistry, Genetic Engineering, Cell Biology