The Origins of Schizophrenia

Published by Columbia University Press 2011

The Origins of Schizophrenia

Edited by: Alan Brown and Paul Patterson

https://doi.org/10.7312/brow15124

Overview
Contents

About this book

The Origins of Schizophrenia synthesizes key findings on a devastating mental disorder that has been increasingly studied over the past decade. Advances in epidemiology, translational neuroscience technology, and molecular and statistical genetics have recast schizophrenia's neurobiological nature, identifying new putative environmental risk factors and candidate susceptibility genes. Providing the latest clinical and neuroscience research developments in a comprehensive volume, this collection by world-renowned investigators answers a pressing need for balanced, thorough information, while pointing to future directions in research and interdisciplinary collaboration.

The book, featuring a foreword by Robert Freedman, M.D., thoroughly examines these topics from the vantage points of epidemiologic, clinical, and basic neuroscience approaches, making it an essential resource for researchers in psychiatry, psychology, and neuroscience and for clinical mental health professionals.

Author / Editor information

Alan S. Brown is Professor of Psychiatry and Epidemiology at Columbia University College of Physicians and Surgeons and the Joseph L. Mailman School of Public Health. He is also director of the Unit in Birth Cohort Studies at the New York State Psychiatric Institute. His honors include the A.E. Bennett Research Award from the Society of Biological Psychiatry, the Bingham Award for Scholarship in Schizophrenia, awards from the National Alliance for Research on Schizophrenia and Depression, and several distinguished lectureships.

Paul H. Patterson is the Anne P. and Benjamin F. Biaggini Professor of Biological Sciences at the California Institute of Technology. Prior to arriving at Caltech, he served on the faculty of the Harvard Medical School for ten years. His honors include the Ulf von Euler Lectureship at the Karolinska Institutet, a Distinguished Investigator Award from the National Alliance for Research on Schizophrenia and Depression, a Javits Neuroscience Investigator Award from the National Institute of Neurological Disorders and Stroke Council, the W. Alden Spencer Award from the Center for Neuroscience, Columbia University, and a visiting professorship at the Institute of Psychiatry, King's College, London.

Reviews

Michael Owen:
An excellent introduction to the origins introduction to the origins of schizophrenia, which brings together a large amount of recent work in a readable and critical manner.

Topics

Frontmatter Publicly Available Download PDF	i
CONTENTS Publicly Available Download PDF	vii
Foreword Robert Freedman Requires Authentication Unlicensed Licensed Download PDF	xi
Acknowledgments Requires Authentication Unlicensed Licensed Download PDF	xiii
Introduction Alan S. Brown and Paul H. Patterson Requires Authentication Unlicensed Licensed Download PDF	1
Overview: Schizophrenia and the Lifetime Trajectory of Psychotic Illness: Developmental Neuroscience and Pathobiology, Redux John L. Waddington, Robin J. Hennessy, Colm M. P. O’Tuathaigh, Olabisi Owoeye and Vincent Russell Requires Authentication Unlicensed Licensed Download PDF	3
PART 1. Clinical Research on Risk Factors for Schizophrenia
Section 1. Environmental Factors: Epidemiologic Studies on the Etiologies of Schizophrenia
1. Maternal Infection and Schizophrenia Alan S. Brown Requires Authentication Unlicensed Licensed Download PDF	25
2. Prenatal Nutrition and the Etiology of Schizophrenia Kristin N. Harper and Alan S. Brown Requires Authentication Unlicensed Licensed Download PDF	58
3. Obstetric Complications and Schizophrenia: Historical Overview and New Directions Mary Clarke, Sarah Roddy and Mary Cannon Requires Authentication Unlicensed Licensed Download PDF	96
4. Maternal Stress During Pregnancy and Schizophrenia Mary C. Iampietro and Lauren M. Ellman Requires Authentication Unlicensed Licensed Download PDF	120
5. Advancing Paternal Age and the Risk for Schizophrenia Sarah Crystal, Karine Kleinhaus, Mary Perrin and Dolores Malaspina Requires Authentication Unlicensed Licensed Download PDF	140
6. Cannabis Use as a Component Cause of Schizophrenia Paola Casadio, Marta Di Forti and Robin M. Murray Requires Authentication Unlicensed Licensed Download PDF	156
Section 2. Genetics and Epigenetics
7. Schizophrenia Genetics: What Have We Learned from Genomewide Association Studies? Alan R. Sanders, Jubao Duan and Pablo V. Gejman Requires Authentication Unlicensed Licensed Download PDF	175
8. Genetic Architecture of Schizophrenia: The Contribution of Copy Number Variation Maria Karayiorgou, Rebecca J. Levy and Bin Xu Requires Authentication Unlicensed Licensed Download PDF	210
9. The Epigenetics of Schizophrenia Iris Cheung, Mira Jakovcevski and Schahram Akbarian Requires Authentication Unlicensed Licensed Download PDF	227
PART 2. Preclinical Research on Etiologies of Schizophrenia
Section 1. Animal Models of Environmental Factors and Schizophrenia
10. Animal Models of the Maternal Infection Risk Factor for Schizophrenia Paul H. Patterson Requires Authentication Unlicensed Licensed Download PDF	255
11. Developmental Vitamin D Deficiency as a Risk Factor for Schizophrenia Xiaoying Cui, Darryl W. Eyles, Thomas H. J. Burne and John J. McGrath Requires Authentication Unlicensed Licensed Download PDF	282
12. Animal Models of Prenatal Protein Malnutrition Relevant for Schizophrenia Lisa M. Tarantino, Teresa M. Reyes and Abraham A. Palmer Requires Authentication Unlicensed Licensed Download PDF	300
13. Animal Models of the Maternal Stress Risk Factor for Schizophrenia Paul H. Patterson Requires Authentication Unlicensed Licensed Download PDF	335
Section 2. Animal Models of Genetic Factors and Schizophrenia Requires Authentication Unlicensed Licensed Download PDF	363
14. DISC1: A New Paradigm for Schizophrenia and Biological Psychiatry David Porteous Requires Authentication Unlicensed Licensed Download PDF	365
15. Mutant Models of Nrg1 and ErbB4: Abnormalities of Brain Structures, Functions, and Behaviors Relevant to Schizophrenia Yachi Chen, Lorna W. Role and David A. Talmage Requires Authentication Unlicensed Licensed Download PDF	382
List of Contributors Requires Authentication Unlicensed Licensed Download PDF	413
Index Requires Authentication Unlicensed Licensed Download PDF	419

Language: English
Publisher: Columbia University Press
Audience: Professional and scholarly;
Pages
- Main content: 448
Illustrations
- Other: 21 illus; 14 tables

eBook

Published: November 1, 2011
ISBN: 9780231521925