Metallo-Drugs: Development and Action of Anticancer Agents

Published by De Gruyter 2018

Metallo-Drugs: Development and Action of Anticancer Agents

Edited by: Astrid Sigel , Helmut Sigel , Eva Freisinger and Roland K.O. Sigel
With contributions by: Imogen Riddell , Stephen J. Lippard , Victor Brabec , Jana Kasparkova , Vijay Menon , Nicholas P. Farrell , V. Venkatesh , Peter J. Sadler , Anil K. Gorle , Erica J. Peterson , Susan Berners-Price , Enzo Alessio , Luigi Messori , Maria V. Babak , Wee Han Ang , Angela Casini , Raymond Wai-Yin Sun , Ingo Ott , Edit Y. Tshuva , Maya Miller , Debbie C. Crans , Lining Yan , Allison Haase , Xiaogai Yang , Christopher Chitambar , Lucia Cardo , Michael John Hannon , Ramon Vilar , Matthew P. Sullivan , Hannah U. Holtkamp , Christian G. Hartinger , Ulrich Schatzschneider , Frank Thévenod , Delphine Denoyer , Sharnel A. S. Clatworthy , Michael Cater , Silvia Ziliotto , Olivia Ogle and Kathryn M. Taylor

Volume 18 in the series Metal Ions in Life Sciences

https://doi.org/10.1515/9783110470734

Overview
Contents

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Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching.

Creating a unique snapshot of current understanding on metallo-drugs.
Providing a view on how knowledge is guiding new metallo-drug design.

Author / Editor information

Helmut and Astrid Sigel, University of Basel, Switzerland; Roland K. O. Sigel and Eva Freisinger, University of Zürich, Switzerland.

Reviews

"The editors are to be congratulated for not only keeping the scientific community abreast of latest developments in this vibrant field of research but for providing an invaluable resource which will no doubt stimulate further cutting edge research in this domain. This volume will also act as an invaluable and indispensable reference source for postgraduate as well as undergraduate teaching. I cannot recommend it highly enough."
Celine J. Marmion in: Coordination Chemistry Reviews 371 (2018) 96–98

"(...) Metallo-Drugs: Development and Action of Anticancer Agents is a nice collection of articles that serves a suitable introduction to either the novice or experienced researcher in the field."
Seth M. Cohen in: Journal of Inorganic Biochemistry 186 (2018) 103

"Volume 18 of MILS is an excellent update on a vibrant field within Bioinorganic Chemistry, the role of metal species in the treatment of cancer. It reflects both the successes of metallo-drugs in the clinic, their failures and shortcomings, and at the same time also promises and hopes for improved drugs in the future. The book is, as stated by the editors, indeed an “essential resource for scientists in this field” and a valuable source for teachers of relevant Bioinorganic Chemistry courses."
Bernhard Lippert in: Inorganica Chimica Acta 479 (2018) 247–248

"(...) This volume currently represents the most up-to-date review within the field of metal-based anticancer agents. (...) A particular strength is the focus on the mechanistic studies and the biological targets, an important feature that makes it different from other reviews recently published. (...) The volume Metallo-Drugs: Development and Action of Anticancer Agents is strongly recommended not only to experienced scientists (either chemists, biologists, biochemists or pharmacologists), but also to researchers in the early stage of their career willing to gain preliminary knowledge on metallodrugs and their biological activity, so as acquire the theoretical background necessary to carry our successful research in the field."
Luca Ronconi in: Transition Metal Chemistry 43 (2018) 377–379

"This latest volume of the series on Metal Ions in Life Sciences will be a valuable addition to libraries of researchers and institutions active in cancer research, but also a helpful source for advanced teaching of the subject."
Hubert Schmidbaur in: Zeitschrift für Naturforschung B 73 (2018) 355-357

Topics

Frontmatter Publicly Available Download PDF	i
About the Editors Publicly Available Download PDF	v
Historical Development and Perspectives of the Series Astrid Sigel, Helmut Sigel and Roland K. O. Sigel Publicly Available Download PDF	vii
Preface to Volume 18 Astrid Sigel, Helmut Sigel, Eva Freisinger and Roland K. O. Sigel Publicly Available Download PDF	ix
Contents Publicly Available Download PDF	xiii
Contributors to Volume 18 Publicly Available Download PDF	xix
Titles of Volumes 1–44 in the Metal Ions in Biological Systems Series Publicly Available Download PDF	xxiii
Contents of Volumes in the Metal Ions in Life Sciences Series Publicly Available Download PDF	xxv
1. CISPLATIN AND OXALIPLATIN: OUR CURRENT UNDERSTANDING OF THEIR ACTIONS Imogen A. Riddell and Stephen J. Lippard Requires Authentication Unlicensed Licensed Download PDF	1
2. POLYNUCLEAR PLATINUM COMPLEXES. STRUCTURAL DIVERSITY AND DNA BINDING Viktor Brabec, Jana Kasparkova, Vijay Menon and Nicholas P. Farrell Requires Authentication Unlicensed Licensed Download PDF	43
3. PLATINUM(IV) PRODRUGS V. Venkatesh and Peter J. Sadler Requires Authentication Unlicensed Licensed Download PDF	69
4. METALLOGLYCOMICS Nicholas P. Farrell, Anil K. Gorle, Erica J. Peterson and Susan J. Berners-Price Requires Authentication Unlicensed Licensed Download PDF	109
5. THE DECEPTIVELY SIMILAR RUTHENIUM(III) DRUG CANDIDATES KP1019 AND NAMI-A HAVE DIFFERENT ACTIONS. WHAT DID WE LEARN IN THE PAST 30 YEARS? Enzo Alessio and Luigi Messori Requires Authentication Unlicensed Licensed Download PDF	141
6. MULTINUCLEAR ORGANOMETALLIC RUTHENIUM-ARENE COMPLEXES FOR CANCER THERAPY Maria V. Babak and Wee Han Ang Requires Authentication Unlicensed Licensed Download PDF	171
7. MEDICINAL CHEMISTRY OF GOLD ANTICANCER METALLODRUGS Angela Casini, Raymond Wai-Yin Sun and Ingo Ott Requires Authentication Unlicensed Licensed Download PDF	199
8. COORDINATION COMPLEXES OF TITANIUM(IV) FOR ANTICANCER THERAPY Edit Y. Tshuva and Maya Miller Requires Authentication Unlicensed Licensed Download PDF	219
9. HEALTH BENEFITS OF VANADIUM AND ITS POTENTIAL AS AN ANTICANCER AGENT Debbie C. Crans, Lining Yang, Allison Haase and Xiaogai Yang Requires Authentication Unlicensed Licensed Download PDF	251
10. GALLIUM COMPLEXES AS ANTICANCER DRUGS Christopher R. Chitambar Requires Authentication Unlicensed Licensed Download PDF	281
11. NON-COVALENT METALLO-DRUGS: USING SHAPE TO TARGET DNA AND RNA JUNCTIONS AND OTHER NUCLEIC ACID STRUCTURES Lucia Cardo and Michael J. Hannon Requires Authentication Unlicensed Licensed Download PDF	303
12. NUCLEIC ACID QUADRUPLEXES AND METALLO-DRUGS Ramon Vilar Requires Authentication Unlicensed Licensed Download PDF	325
13. ANTITUMOR METALLODRUGS THAT TARGET PROTEINS Matthew P. Sullivan, Hannah U. Holtkamp and Christian G. Hartinger Requires Authentication Unlicensed Licensed Download PDF	351
14. METALLOINTERCALATORS AND METALLOINSERTORS: STRUCTURAL REQUIREMENTS FOR DNA RECOGNITION AND ANTICANCER ACTIVITY Ulrich Schatzschneider Requires Authentication Unlicensed Licensed Download PDF	387
15. IRON AND ITS ROLE IN CANCER DEFENSE: A DOUBLE-EDGED SWORD Frank Thévenod Requires Authentication Unlicensed Licensed Download PDF	437
16. COPPER COMPLEXES IN CANCER THERAPY Delphine Denoyer, Sharnel A. S. Clatworthy and Michael A. Cater Requires Authentication Unlicensed Licensed Download PDF	469
17. TARGETING ZINC(II) SIGNALLING TO PREVENT CANCER Silvia Ziliotto, Olivia Ogle and Kathryn M. Taylor Requires Authentication Unlicensed Licensed Download PDF	507
SUBJECT INDEX Requires Authentication Unlicensed Licensed Download PDF	531

(Deutsch)

Language: English
Publisher: De Gruyter
Audience: Scientists in biochemistry, inorganic chemistry, medicine, pharmacy, toxicology, and molecular biology.
Pages
- Front matter: 42
- Main content: 546
Illustrations
- Coloured Illustrations: 150
- Tables: 100
Keywords: Anorganische Chemie; Bioanorganische Chemie; Arzneimitteldesign; Koordinationschemie

eBook

Published: February 5, 2018
ISBN: 9783110470734

Hardcover

Published: February 5, 2018
ISBN: 9783110469844