Cellular Responses to Stress

Published by Princeton University Press 1999

Cellular Responses to Stress

Edited by: C. P. Downes , C. R. Wolf and D. P. Lane

Volume 85 in the series Princeton Legacy Library

https://doi.org/10.1515/9781400865048

Overview
Contents

About this book

Cellular Responses to Stress brings together a group of scientists who work on different but interrelated aspects of cellular stress responses. The book provides state-of-the-art information on the wide spectrum of ways in which cells can respond to different forms of stress induced by chemicals, oxidants, and DNA-damaging agents. Mechanisms are described that involve altered uptake and efflux of chemical agents, intracellular detoxification, and DNA damage responses. Many of these changes trigger a cascade of reactions mediated by stress-activated signaling pathways, which have the capacity to determine whether a cell will survive or die. The spectrum of topics covered in this book aims to provide a broad overview of our current knowledge of the different forms of adaptive response systems.

It is hoped that this text will stimulate further research to establish the relative cellular role of specific response pathways and will enable us to gain a deeper understanding of the mechanisms that allow cells to live or die. This book will be valued by university researchers at all levels, industrial scientists in the pharmaceutical and biotechnology industries, and clinical researchers.

Originally published in 1999.

The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

Topics

Frontmatter Publicly Available Download PDF	i
Contents Publicly Available Download PDF	v
Preface Requires Authentication Unlicensed Licensed Download PDF	vii
Abbreviations Requires Authentication Unlicensed Licensed Download PDF	ix
1. Signal transduction by the c-Jun N-terminal kinase Roger J. Davis Requires Authentication Unlicensed Licensed Download PDF	1
2. Roles of the AMP-activated/SNFI protein kinase family in the response to cellular stress D. Grahame Hardie Requires Authentication Unlicensed Licensed Download PDF	13
3. Making the connection: coupling of stress-activated ERK/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signalling modules to extracellular stimuli and biological responses John M. Kyriakis Requires Authentication Unlicensed Licensed Download PDF	29
4. Stress-activated MAP kinase (mitogen-activated protein kinase) pathways of budding and fission yeasts Jonathan B.A. Millar Requires Authentication Unlicensed Licensed Download PDF	49
5. Protein kinase cascades in intracellular signalling by interleukin-1 and tumour necrosis factor Jeremy Saklatvala, Jon Dean and Andrew Finch Requires Authentication Unlicensed Licensed Download PDF	63
6. Regulation of actin dynamics by stress-activated protein kinase 2 (SAPK2)-dependent phosphorylation of heat-shock protein of 27 kDa (Hsp27) Jacques Landry and Jacques Huot Requires Authentication Unlicensed Licensed Download PDF	79
7 DNA-dependent protein kinase and related proteins Graeme C.M. Smith, Nullin Divecha, Nicholas D. Lakin and Stephen P. Jackson Requires Authentication Unlicensed Licensed Download PDF	91
8. Stress-induced activation of the heat-shock response: cell and molecular biology of heat-shock factors Jose J. Cotto and Richard I. Morimoto Requires Authentication Unlicensed Licensed Download PDF	105
9. Transcriptional regulation via redox-sensitive iron-sulphur centres in an oxidative stress response Bruce Demple, Elena Hidalgo and Huangen Ding Requires Authentication Unlicensed Licensed Download PDF	119
10. Adaptive responses to environmental chemicals C.R. Wolf, G. Smith, A.G. Smith, K. Brown and C.J. Henderson Requires Authentication Unlicensed Licensed Download PDF	129
11. Cellular response to cancer chemopreventive agents: contribution of the antioxidant responsive element to the adaptive response to oxidative and chemical stress John D. Hayes, Elizabeth M. Ellis, Gordon E. Neal, David J. Harrison and Margaret M. Manson Requires Authentication Unlicensed Licensed Download PDF	141
Index Requires Authentication Unlicensed Licensed Download PDF	169

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