Editors:
- Presents a general introduction to skin permeation and disposition of chemical compounds in the first part to review the basic study as well as the R&D on topical and transdermal drug delivery systems and cosmetics
- Provides comments from dermatologists and pharmacists, which are especially useful for R&D in the industry
- Discusses safety assessment of topically applied compounds, which only a few books pay attention to
- Contains many contributions by Japanese and other Asian academics and researchers
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Table of contents (39 chapters)
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Front Matter
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General Introduction
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Front Matter
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Basic Formulations Applied to Skin
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Front Matter
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Skin Penetration Enhancement
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Front Matter
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About this book
This book reviews skin permeation and disposition of chemical compounds. Skin is utilized as an administration site for transdermal drug delivery systems, topical drug formulations, cosmeceuticals, and cosmetics. Their usefulness is closely related to the permeation and disposition of entrapped active ingredients through and into the skin. Skin permeation, disposition, and metabolism of chemicals are first summarized in the general introduction. Then primary topical formulations are explained in the second part, “Basic Formulations Applied to Skin”. The explanation for the active compounds and formulations are of the most important parts required to fabricate these formulations. Skin absorption of chemicals is generally much lower than oral and the other mucosal absorptions, so that skin-penetration enhancement is a key issue to have good formulations topically applied. Part 3 presents “Skin Penetration Enhancement”. In addition, Part 4, “Selection of Topically Applied Chemical Candidates”, deals with selection methods of topically applied ingredients for transdermal drug delivery systems, topical drug formulations, cosmeceuticals, and cosmetics. Parts 5 and 6, “Safety Assessment of Topically Applied Compounds“ and “Experimental Methods of Skin Permeation“, respectively, show safety issues and experimental methods for topical formulations. The final part consists of comments on therapeutic and cosmetic formulations by medical doctors and pharmacists. Their comments are especially helpful for pharmaceutical and cosmetic researchers who study dermatopharmacokinetics and topical formulations.
This volume is particularly useful for those working in R&D, graduate students, and educators in the area of pharmaceutics, cosmetic sciences, dermatological sciences, pharmacology, toxicology, biopharmacy, pharmacokinetics, physical pharmacy, chemical engineering, and related fields.
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Editors and Affiliations
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President, Josai International University, Togane, Japan
Kenji Sugibayashi
About the editor
Kenji Sugibayashi, Ph.D.
President,
Josai International University
and
Professor,
Graduate School of Pharmaceutical Sciences and Faculty of Pharmacy and Pharmaceutical Sciences, Josai University
Bibliographic Information
Book Title: Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds
Editors: Kenji Sugibayashi
DOI: https://doi.org/10.1007/978-4-431-56526-0
Publisher: Springer Tokyo
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Japan KK 2017
Hardcover ISBN: 978-4-431-56524-6Published: 15 December 2017
Softcover ISBN: 978-4-431-56812-4Published: 06 September 2018
eBook ISBN: 978-4-431-56526-0Published: 28 November 2017
Edition Number: 1
Number of Pages: X, 428
Number of Illustrations: 75 b/w illustrations, 78 illustrations in colour
Topics: Pharmaceutical Sciences/Technology, Dermatology, Medicinal Chemistry