Overview
- Demonstrates how ion channels and transporters could be used as tumor markers
- Provides novel transport-focused approaches in anti-cancer treatment
- Opens up new perspectives in treatment strategies for cancer
Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology (REVIEWS, volume 183)
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Table of contents (8 chapters)
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Front Matter
Keywords
About this book
This third and final volume in the "Ion Transport in Tumor Biology" collection presents novel diagnostic and therapeutic approaches in cancer based on the exploitation of ion transport proteins. The authors critically examine several transportome members, particularly Na+, K+, Ca2+, and Cl- channels, as well as organic solute carriers regarding their suitability as therapeutic targets. Synergistic effects resulting from the combined use of classical cytostatics with ion transport-inhibiting drugs are pointed out, and the capability of bispecific antibodies to function as anticancer drugs is discussed.
As readers will also learn, the use of ion channel inhibitors could improve the outcome of radiotherapy because the development of radio-resistance during radiotherapeutic treatment often correlates with increases in the expression levels and conductance of ion channels. The translational topics of this volume form a bridge between biochemical research and therapeutic application.
As part of a three-volume collection, this book will fascinate members of the active research community, as well as clinicians in the cancer field.Editors and Affiliations
Bibliographic Information
Book Title: Targets of Cancer Diagnosis and Treatment
Book Subtitle: Ion Transport in Tumor Biology
Editors: Christian Stock, Luis A. Pardo
Series Title: Reviews of Physiology, Biochemistry and Pharmacology
DOI: https://doi.org/10.1007/978-3-031-03994-2
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022
Hardcover ISBN: 978-3-031-03993-5Published: 06 May 2022
Softcover ISBN: 978-3-031-03996-6Published: 07 May 2023
eBook ISBN: 978-3-031-03994-2Published: 05 May 2022
Series ISSN: 0303-4240
Series E-ISSN: 1617-5786
Edition Number: 1
Number of Pages: X, 277
Number of Illustrations: 10 b/w illustrations, 20 illustrations in colour
Topics: Cancer Research, Medical Biochemistry, Pharmacology/Toxicology, Human Physiology, Oncology, Cell Physiology