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The Renin Angiotensin System in Cardiovascular Disease

  • Book
  • © 2023

Overview

Editors:
  1. Naranjan S. Dhalla

    1. Institute of Cardiovascular Sciences, St. Boniface Hospital, Manitoba, Canada

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  2. Sukhwinder K. Bhullar

    1. Institute of Cardiovascular Sciences, St. Boniface Hospital, Winnipeg, Canada

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  3. Anureet K. Shah

    1. California State University Los Angeles, Los Angeles, USA

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  • Includes state-of-the-art research on the role of renin-angiotensin system
  • Discusses the interaction between different receptors and signaling pathways for the Renin-angiotensin system
  • Showcases different molecular targets in the renin-angiotensin pathway for cardiovascular drug development

Part of the book series: Advances in Biochemistry in Health and Disease (ABHD, volume 24)

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Table of contents (25 chapters)

  1. Front Matter

    Pages i-xviii
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  2. Modulatory Aspects of Renin Angiotensin System

    1. Front Matter

      Pages 1-1
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    2. Renin–Angiotensin–Aldosterone System and LOX-1 Interaction in Hypertension with a Focus on Modulation of the Immune System

      • Weijia Cheng, Fang Shao, Jawahar L. Mehta, Xianwei Wang
      Pages 3-21

    3. Renin Angiotensin System and Thyroid Hormone Crosstalk: From Experimental Approaches to Clinical Perspectives

      • Laura Sabatino, Dario Genovesi, Cristina Vassalle
      Pages 23-37

    4. Crosstalk Between Abnormal Electrical Activity and Angiotensin II Cell Signaling in the Hyperglycemic Mammalian Heart

      • Belma Turan
      Pages 39-62

    5. Cardiovascular Physiopathology of Angiotensin II and Its Plasma and Nuclear Envelop Membranes’ Receptors

      • Danielle Jacques, Ghassan Bkaily
      Pages 63-80

    6. Epigenetic miRNA Mediated Regulation of RAS in Cardiovascular Diseases

      • Aylin Caliskan, Samantha A. W. Crouch, Seema Dangwal
      Pages 81-103

    7. Epigenetics Changes in Renin Angiotensin System (RAS): Application of Biosensors for Monitoring These Changes

      • Zahra Sepehri, Zohreh Kiani, Farkhonde Sarhaddi, Mehdi Sepehri, Surandi Krishna Kumari Wadu Mesthri, Hasan Bagheri
      Pages 105-113

    8. Genetic Polymorphisms in the Renin-Angiotensin-Aldosterone System

      • Tomasz Rechciński
      Pages 115-130

    9. Mitochondria: A Key Protagonist of the Renin Angiotensin System

      • Rini Varghese, Anuradha Majumdar
      Pages 131-144

    10. The Renin Angiotensin System at the Time of COVID-19

      • Karsten Grote, Julian Kreutz, Ann-Christin Schaefer, Birgit Markus, Bernhard Schieffer
      Pages 145-156

  3. Pathophysiological Implications of Renin Angiotensin System

    1. Front Matter

      Pages 157-157
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    2. A Ying-Yang Perspective on the Renin Angiotensin System in Cardiovascular Disease

      • Sarfaraz Ahmad, Carlos M. Ferrario
      Pages 159-172

    3. Central Control of Sympathetic and Renin Angiotensin System in the Development of Hypertension

      • Paul Ganguly, Alyaman Almiro, Ahmad Dawalibi, Tarek Al Mahayni, Khalid Said Mohammad
      Pages 173-185

    4. Role Renin Angiotensin System in Hypertension

      • Prithiviraj Nagarajan
      Pages 187-200

    5. Comparing the Influence of Angiotensin II and TGFβ1 on Cardiac Fibroblasts; Myofibroblast Plasticity and Resistance to Apoptosis

      • Besher Abual’anaz, Sunil G. Rattan, Ian M. C. Dixon
      Pages 201-210

    6. Role of Renin Angiotensin System in the Pathophysiology of Coronary Heart Disease: Advancements in Diagnosis, Therapy and Preventive Strategies

      • Jinit K. Mehta, Meheli A. Banerjee, Priyanka H. Shah, Ginpreet Kaur, Harpal S. Buttar
      Pages 211-235

    7. Renin Angiotensin System in the Pathophysiology of Diabetic Cardiomyopathy in Type 2 Diabetes

      • Karina P. Gomes, Anshul S. Jadli, Vaibhav B. Patel
      Pages 237-258

    8. Renin Angiotensin System and Obesity-Related Organ Damage

      • Isabel Galceran, Anna Oliveras
      Pages 259-273

    9. Renin Angiotensin System in Aging and Regeneration

      • Neha Rawal, Anupam Mittal, Madhu Khullar
      Pages 275-289
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Keywords

About this book

This book on “Renin-Angiotensin System in Cardiovascular Disease” includes 25 chapters, which are organized in three sections, namely (i) modulatory aspects, (ii) pathophysiological aspects, and (iii) pharmacotherapeutic aspects. It includes an updated as well as comprehensive knowledge about molecular and cellular aspects for the role of the renin-angiotensin system (RAS) in the pathophysiology and therapy of cardiovascular diseases such as hypertension, atherosclerosis, ischemic heart disease, and heart failure. This book emphasizes the molecular and cellular mechanisms, signaling transduction pathways involved in the development of different cardiovascular diseases due to the prolonged activation of RAS. Furthermore, biochemical mechanisms are outlined for the inhibition of this system by the blockade of angiotensin converting enzyme as well as angiotensin II type 1 receptors in patients suffering from cardiovascular abnormalities. Since cardiovascular disease is the number onecause of death worldwide, leading to approximately 17.9 million deaths each year, there is a keen interest in understanding the pathogenesis and improving its therapy. In this regard, we can attest that this book provides ample information about essential components of RAS and their role in the development of cardiovascular disease.


From the selection of recognized global experts in their area of investigation, this book can be seen to cover diverse cardiovascular aspects and molecular and cellular mechanisms of angiotensin II action for the development of different cardiovascular abnormalities. It is our contention that this book will be most suitable for promoting knowledge in the field of RAS biology and will be of great interest to health professionals involved in both experimental and clinical cardiology as well as academic investigators and cardiovascular scientists, graduate students, and fellows worldwide.

Editors and Affiliations

  • Institute of Cardiovascular Sciences, St. Boniface Hospital, Manitoba, Canada

    Naranjan S. Dhalla

  • Institute of Cardiovascular Sciences, St. Boniface Hospital, Winnipeg, Canada

    Sukhwinder K. Bhullar

  • California State University Los Angeles, Los Angeles, USA

    Anureet K. Shah

Bibliographic Information

  • Book Title: The Renin Angiotensin System in Cardiovascular Disease

  • Editors: Naranjan S. Dhalla, Sukhwinder K. Bhullar, Anureet K. Shah

  • Series Title: Advances in Biochemistry in Health and Disease

  • DOI: https://doi.org/10.1007/978-3-031-14952-8

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023

  • Hardcover ISBN: 978-3-031-14951-1Published: 03 January 2023

  • Softcover ISBN: 978-3-031-14954-2Published: 04 January 2024

  • eBook ISBN: 978-3-031-14952-8Published: 01 January 2023

  • Series ISSN: 2512-2142

  • Series E-ISSN: 2512-2150

  • Edition Number: 1

  • Number of Pages: XVIII, 452

  • Number of Illustrations: 17 b/w illustrations, 54 illustrations in colour

  • Topics: Biomedicine, general, Physiology, Cardiology, Medical Biochemistry

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