Volume 2 Biomedical Applications

Published by De Gruyter 2023

Volume 2 Biomedical Applications

Edited by: Malgorzata Lekka , Daniel Navajas , Manfred Radmacher and Alessandro Podestà

Part of the multi-volume work Mechanics of Cells and Tissues in Diseases

In the series De Gruyter STEM

https://doi.org/10.1515/9783110989380

Overview
Contents

About this book

This book is dedicated to the discussion of several biomedical applications of the mechanical phenotyping of cells and tissues to specific disease models. The topical chapters on mechanics in disease are preceded by chapters describing cell and tissue structure and their relationship with the biomechanical properties, as well as by the description of dedicated sample preparation methods for the nano- and microscale mechanical measurements.

Introduces the basics of physics and biology of the cell before delving into the mechanics of diseases.
With detailed explanation of sample preparation and characterization techniques.
Plenty of real-life examples, from heart infarction to cancer.

Author / Editor information

__Małgorzata Lekka holds a PhD in physics with a specialization in medical physics. She studied physics at the Jagiellonian University (Kraków, Poland), completed in 1993. In 1993, she started to work at the Institute of Nuclear Physics, Polish Academy of Sciences (IFJ PAN, Kraków, Poland), where she obtained the PhD in 1998 in physics (specialization: biophysics) with the thesis focused on the elasticity of cancerous cells measured by atomic force microscopy (AFM), followed by habilitation in 2008. Since 2016, she is a full professor at the Institute of Nuclear Physics, Polish Academy of Sciences (IFJ PAN, Kraków, Poland. From 2016, she headed the Department of Biophysical Microstructures at the IFJ PAN (https://www.ifj.edu.pl/oddzialy/no5/nz55). She has published over 140 papers in international peer-reviewed journals (H-index 32, researcher identifiers: A-3706-2016 (WoS), 0000-0003-0844-8662 (Orcid), and 7003401456 (Scopus)).

__Daniel Navajas, University Barcelona, Spain.

__Alessandro Podestà (AP) holds a PhD in Materials Science and since 2015 he is associate professor at the Department of Physics "Aldo Pontremoli" of the University of Milano, Italy. AP has published about 100 papers on international peer-reviewed journals (H-index 30, complete bibliographic record with metrics at: https://www.webofscience.com/wos/author/rid/E-6568-2010; ORCID: https://orcid.org/0000-0002-4169-6679). In 2012 AP obtained the National Academic Qualification (ASN) to apply for Full Professor positions in Experimental Physics of Matter (02/B1).

Since 1999, AP is active in the field of characterization of physical and chemical properties of systems and interfaces at the nanoscale by Atomic Force Microscopy (AFM) techniques. AP leads the AFM group of the Interdisciplinary Centre for Nanostructured Materials and Interfaces (CIMaINa) of Università degli Studi di Milano. The research activity of the AFM laboratory developed over the years under the guidance of AP since its foundation in 1999, along two parallel but strongly interconnected tracks: the development of experimental techniques and protocols based on atomic force microscopy, and the application of such protocols to the study of nanostructured systems and interfaces. The synergistic combination of research and development activities related to atomic force microscopy has always characterized the scientific approach of AP within the Physics Department and CIMAINA @UNIMI; this expertise has been enhanced at European and international level in funded research projects and in commissioned research activities.

__Manfred Radmacher, University Bremen, Germany.

Topics

Frontmatter Publicly Available Download PDF	I
Preface Publicly Available Download PDF	V
Acknowledgment Publicly Available Download PDF	VII
Table of Contents of Volume 2 – Biomedical Applications Publicly Available Download PDF	IX
Table of Contents Volume 1 – Biomedical Methods Publicly Available Download PDF	XII
Contributing Authors Publicly Available Download PDF	XV
Cell and Tissue Structure
4.1 Cell Structure: An Overview Małgorzata Lekka Requires Authentication Unlicensed Licensed Download PDF	1
4.2 The Cytoskeleton Wolfgang H. Goldmann Requires Authentication Unlicensed Licensed Download PDF	7
4.3 Cell Membrane and Glycocalyx Dorota Gil, Marta Zarzycka and Piotr Laidler Requires Authentication Unlicensed Licensed Download PDF	23
4.4 Functions of Plant Cell Walls in Root Growth and Environmental Interactions Ellen Zelinsky and Charles T. Anderson Requires Authentication Unlicensed Licensed Download PDF	33
4.5 Extracellular Matrix Dorota Gil, Marta Zarzycka and Piotr Laidler Requires Authentication Unlicensed Licensed Download PDF	47
4.6 Mechanotransduction Carsten Schulte Requires Authentication Unlicensed Licensed Download PDF	53
Sample Preparation
5.1 Cell Culture Carmela Rianna and Carsten Schulte Requires Authentication Unlicensed Licensed Download PDF	77
5.2 Tissue Preparation Manuela Brás, Joanna Zemła and Ramon Farré Requires Authentication Unlicensed Licensed Download PDF	91
5.3 Soft Hydrogels Mimicking the Extracellular Matrix Arnaud Millet and Carmela Rianna Requires Authentication Unlicensed Licensed Download PDF	105
5.4 Preparation and Deposition of Plant Roots for AFM Nanomechanical Measurements Harinderbir Kaur, Christian Godon, Jean-Marie Teulon, Thierry Desnos and Jean-Luc Pellequer Requires Authentication Unlicensed Licensed Download PDF	123
Mechanics in Diseased Cells and Tissues
6.1 Cardiovascular Diseases Martin Pesl, Jan Pribyl, Petr Dvorak, Zdenek Starek, Petr Skladal, Kristian Brat and Vladimir Rotrekl Requires Authentication Unlicensed Licensed Download PDF	137
6.2 Respiratory Diseases Ramon Farré and Daniel Navajas Requires Authentication Unlicensed Licensed Download PDF	163
6.3 Cancer Małgorzata Lekka, Manfred Radmacher, Arnaud Millet and Massimo Alfano Requires Authentication Unlicensed Licensed Download PDF	191
6.4 Blood Cells Marco Girasole and Simone Dinarelli Requires Authentication Unlicensed Licensed Download PDF	231
6.5 Diabetes and Endothelial Nanomechanics Marta Targosz-Korecka Requires Authentication Unlicensed Licensed Download PDF	259
6.6 Chronic Liver Diseases Arnaud Millet and Thomas Decaens Requires Authentication Unlicensed Licensed Download PDF	269
6.7 Mechanics of Dupuytren’s Disease Prem Kumar Viji Babu and Manfred Radmacher Requires Authentication Unlicensed Licensed Download PDF	277
6.8 Intermediate Filaments Wolfgang H. Goldmann Requires Authentication Unlicensed Licensed Download PDF	281
6.9 Laminopathies Manfred Radmacher Requires Authentication Unlicensed Licensed Download PDF	299
6.10 Integrative Approaches Using AFM to Study Pathogenic Bacteria and Infection Lorena Redondo-Morata, Vincent Dupres, Sébastien Janel and Frank Lafont Requires Authentication Unlicensed Licensed Download PDF	303
6.11 Stiffening of the Plant Root Cell Wall Induced by a Metallic Stress Christian Godon, Harinderbir Kaur, Jean-Marie Teulon, Shu-wen W. Chen, Thierry Desnos and Jean-Luc Pellequer Requires Authentication Unlicensed Licensed Download PDF	333
Outlook
7.1 Mechanics of Diseases: An Outlook Hans Oberleithner Requires Authentication Unlicensed Licensed Download PDF	343
Subject Index (Volume 1 & Volume 2) Requires Authentication Unlicensed Licensed Download PDF	349

(Deutsch)

Language: English
Publisher: De Gruyter
Audience: Graduate students in Physics, Medicine, Life Sciences; researchers in Biophysics, Biomedical Engineering, Biotechnology.
Pages
- Front matter: 19
- Main content: 351
Illustrations
- Illustrations: 8
- Coloured Illustrations: 67
- Coloured Tables: 10
Keywords: Biophysik; Blutkrankheit; Dupuytren-Kontraktur; Extrazelluläre Matrix; Gewebe; Gewebekultur; Herzkrankheit; Krankheit; Krebs; Molekulare Biophysik; Muskelkrankheit; Optische Pinzette; Rasterkraftmikroskopie; Zellkultur

eBook

Published: February 20, 2023
ISBN: 9783110989380

Paperback

Published: February 20, 2023
ISBN: 9783110999723