Peptide Antibiotics Biosynthesis and Functions: Enzymatic Formation of Bioactive Peptidesand Related Compounds

Published by De Gruyter 1982

Peptide Antibiotics Biosynthesis and Functions

Enzymatic Formation of Bioactive Peptidesand Related Compounds

Edited by: Horst Kleinkauf and Hans von Döhren

https://doi.org/10.1515/9783110837834

Contents

Frontmatter Publicly Available Download PDF	I
Preface Publicly Available Download PDF	V
Foreword Publicly Available Download PDF	VII
Contents Publicly Available Download PDF	IX
I. Introduction
A Survey of Enzymatic Peptide Formation Horst Kleinkauf and Hans von Döhren Requires Authentication Unlicensed Licensed Download PDF	1
On Biosynthesis of the Cyclic Antibiotics Gramicidin S and Tyrocidine, and of Linear Gramicidin Fritz Lipmann Requires Authentication Unlicensed Licensed Download PDF	23
II. Pathways and Genetics
Chemistry and Biosynthesis of the Poly (y-D-Glutamyl) Capsule in Bacillus licheniformis Frederic A. Troy Requires Authentication Unlicensed Licensed Download PDF	47
Recent Developments with Cell free Extracts on the Enzymic Biosynthesis of Penicillins and Cephalosporins Derek J. Hook, Richard P. Elander and Robert B. Morin Requires Authentication Unlicensed Licensed Download PDF	85
Accumulation of <5-(L-a-Aminoadipyl)-L-Cysteinyl-D-Valine Derivatives by Mutants of Cephalosporium acremonium Hideo Shirafuji and Masahiko Yoneda Requires Authentication Unlicensed Licensed Download PDF	97
Genetic Studies on the Biosynthesis of Actinomycin Ullrich Keller, Marion Ebert and Horst Kleinkauf Requires Authentication Unlicensed Licensed Download PDF	101
Role of Peptides from Mycobacillin-Synthesizing System in the Biosynthesis of Mycobacillin Subhabrata Sengupta and Susil Kumar Bose Requires Authentication Unlicensed Licensed Download PDF	109
III. Fermentations and Peptide Production
Environmental Influences on the Dynamics of the Gramicidin S Fermentation Erick J. Vandamme, Dirk Leyman, Dirk De Buyser, Patrick De Visscher, Jan Spriet, Ghislain C. Vansteenkiste, Osamu Nimi, Agnès Poirier and Arnold L. Demain Requires Authentication Unlicensed Licensed Download PDF	115
Production of Gramicidin S-Synthetase from Bacillus brevis ATCC 9999 by Batch Fermentation Hans Jürgen Aust and Hans von Döhren Requires Authentication Unlicensed Licensed Download PDF	137
Studies on the Gramicidin S-Synthetase Production in Bacillus brevis ATCC 9999 in C- and P-Limited Chemostat Cultures Chung-Wai Chiu, Thomas Bernhard and Hans Werner Dellweg Requires Authentication Unlicensed Licensed Download PDF	149
On the Role of L-Leucine in the Control of Bacitracin Formation by Bacillus licheniformis Hans Ivar Haavik and Øystein Frøyshov Requires Authentication Unlicensed Licensed Download PDF	155
Current Research in Ergot Peptide Synthesis by Claviceps purpurea Ullrich Keller, Rainer Zocher and Gunda Kraepelin Requires Authentication Unlicensed Licensed Download PDF	161
Applications of Multienzyme Systems in the Production of Peptide Antibiotics H. v. Döhren Requires Authentication Unlicensed Licensed Download PDF	169
IV. Enzyme Systems
The Fidelity of Gramicidin S-Synthetase with Particular Reference to the Amino Acids Cyclohexylalanine and Phenylalanine Søren G. Laland, Kjell Aarstad and Trine-Lise Zimmer Requires Authentication Unlicensed Licensed Download PDF	183
Some Characteristics of Gramicidin S-Synthetase Obtained from Mutants of Bacillus brevis which could not form DPhenylalanyl- L-Prolyl Diketo-Piperazine Yoshitaka Saito Requires Authentication Unlicensed Licensed Download PDF	195
Kinetics of Amino Acid Activation in Gramicidin S Synthesis Reinhold Kittelberger, Michael Altmann and Hans von Döhren Requires Authentication Unlicensed Licensed Download PDF	209
The Temperature Dependence of the Partial Processes Involved in the Biosynthesis of Gramicidin S Joachim Vater, Norbert Mallow, Sabine Gerhardt and Horst Kleinkauf Requires Authentication Unlicensed Licensed Download PDF	219
Further Characterization of Multienzyme Fragments of Gramicidin S Synthetase obtained from Gramicidin S Nonproducer Mutants Dagmar Bothe, Hans von Döhren, Harald Zschiedrich, Ali El-Samaraie, Michael Krause and Horst Kleinkauf Requires Authentication Unlicensed Licensed Download PDF	233
Limited Proteolysis: Studies on the Multienzyme GS2 of Gramicidin S-Synthetase Michael Altmann, Hans von Döhren, Ali El-Samaraie, Reinhold Kittelberger, Mrinalini S. Pore and Horst Kleinkauf Requires Authentication Unlicensed Licensed Download PDF	243
Tryptic Cleavage of the Heavy Enzyme of Gramicidin SSynthetase Kjell Aarstad and Øystein Frøyshov Requires Authentication Unlicensed Licensed Download PDF	253
Use of Affinity Chromatography in Purification of Gramicidin S-Synthetases Christa Schröter, Wolfgang Rönspeck, Michael Altmann, Hans von Döhren and Horst Kleinkauf Requires Authentication Unlicensed Licensed Download PDF	259
A Survey on the Use of Affinity Chromatography for Studying the Mechanism of Gramicidin S Formation Cath. Christiansen, Berit Nordvi, Trine-Lise Zimmer and Søren G. Laland Requires Authentication Unlicensed Licensed Download PDF	265
Other Synthetases
Enniatin-Synthetase: Studies on the Activation of Residues Involved in Enniatin Synthesis Rainer Zocher, Ullrich Keller and Horst Kleinkauf Requires Authentication Unlicensed Licensed Download PDF	269
Biosynthesis of Antibiotic Peptides Polymyxin E and Gramicidin A Kiyoshi Kurahashi, Sadaaki Komura, Katsuhiko Akashi and Chika Nishio Requires Authentication Unlicensed Licensed Download PDF	275
Component I Protein of Bacitracin Synthetase: A Multifunctional Protein Hiroaki Ishihara, Ikuzo Ogawa and Kensuke Shimura Requires Authentication Unlicensed Licensed Download PDF	289
Bacitracin Synthetase Subenzymes and Tail Peptide Formation in Bacitracin Ljubisa Vitkovic and Peter Pfaender Requires Authentication Unlicensed Licensed Download PDF	297
Bacitracin Synthetase. Tryptic Cleavage of Enzymes B and C Øystein Frøyshov and Anita Mathiesen Requires Authentication Unlicensed Licensed Download PDF	307
Edeine Synthetase: Evidence for Bidirectional Synthesis of Edeines Zofia Kurylo-Borowska and Joy Heaney-Kieras Requires Authentication Unlicensed Licensed Download PDF	315
Biosynthesis of Leupeptin Kayoko Suzukake, Makoto Hori and Hidemi Hayashi Hamao Umezawa Requires Authentication Unlicensed Licensed Download PDF	325
Biosynthesis of Carnosine and Related Peptides Karl Bauer, Peter Jungblut and Horst Kleinkauf Requires Authentication Unlicensed Licensed Download PDF	337
Inhibition of Carnosine Synthetase by Spermidine James E. Seely and Finley D. Marshall Requires Authentication Unlicensed Licensed Download PDF	347
Corynebacterium species Folylpoly-y-Glutamate Synthetase Barry Shane Requires Authentication Unlicensed Licensed Download PDF	353
Discussion Peptide Synthetases - Problems and Properties Summary of a round-table discussion held on Sept. 5th, 1980 Requires Authentication Unlicensed Licensed Download PDF	369
V. Possible Functions of Peptide Antibiotics in their Producer Organisms
A Survey of Possible Functions of Peptide Antibiotics in the Producer Organisms Mohamed A. Marahiel and Hans von Döhren Requires Authentication Unlicensed Licensed Download PDF	373
Tyrocidine Induced Sporulation of Bacillus brevis in a Medium Lacking A Nitrogen Source Hansjürgen Ristow, Joseph Russo, Eleanor Stochaj and Henry Paulus Requires Authentication Unlicensed Licensed Download PDF	381
Studies on the Role of Gramicidin S in the Life Cycle of its Producer Bacillus brevis ATCC 9999 Mohamed A. Marahiel, Wolf Danders, Gunda Kraepelin and Horst Kleinkauf Requires Authentication Unlicensed Licensed Download PDF	389
Investigations on the Function of Amatoxins in Amanita Species: A Case for Amatoxins as Potential Regulators of Transcription James F. Preston, Billy E. C. Johnson, Michael Little, Tony Romeo, Henry J. Stark and Jerald E. Mullersman Requires Authentication Unlicensed Licensed Download PDF	399
Structural Requirements for the Biological Activity of Polymyxin B L. K. Ramachandran, B. R. Srinivasa and G. Radhakrishna Requires Authentication Unlicensed Licensed Download PDF	427
Gramicidin S - Fragments Generated by Mild Acid Hydrolysis of the Antibiotic Johann Salnikow and Gisela Haeselbarth Requires Authentication Unlicensed Licensed Download PDF	445
Relevance of the Association of Polymyxin Biosynthetic Complex with Membrane DNA During Growth and Sporulation of B. polymyxa N. Satwant Kaur, G. N. Chandrasekaran, N. Vasantha and Kunthala Jayaraman Requires Authentication Unlicensed Licensed Download PDF	453
Author Index Requires Authentication Unlicensed Licensed Download PDF	467
Subject Index Requires Authentication Unlicensed Licensed Download PDF	469

Language: English
Publisher: De Gruyter
Edition: Reprint 2019
Pages
- Front matter: 11
- Main content: 479
Illustrations
- Other: Num. figs. and tables
Keywords: Peptide antibiotics -- Physiological effect; Peptide antibiotics -- Synthesis; Microbiological synthesis

eBook

Published: March 20, 2023
ISBN: 9783110837834

Hardcover

Published: March 1, 1982
ISBN: 9783110084849