Insulin, chemistry, structure, and function of insulin and related hormones: Proceedings of the Second International Insulin Symposium, Aachen, Germany, September 4–7, 1979

Published by De Gruyter 1980

Insulin, chemistry, structure, and function of insulin and related hormones

Proceedings of the Second International Insulin Symposium, Aachen, Germany, September 4–7, 1979

Edited by: Dietrich Brandenburg and Axel Wollmer

https://doi.org/10.1515/9783111646190

Contents

Frontmatter Publicly Available Download PDF	I
ACKNOWLEDGEMENTS Publicly Available Download PDF	VIII
Preface Publicly Available Download PDF	IX
CONTENTS Publicly Available Download PDF	XI
INTRODUCTION Requires Authentication Unlicensed Licensed Download PDF	1
SECTION I. STRUCTURE OF INSULIN
A Comparison Between the Insulin Molecules in 2-Zinc and 4-Zinc Insulin Crystals E.J. Dodson, G.G. Dodson, Reynolds and D. Vallely Requires Authentication Unlicensed Licensed Download PDF	9
Crystal Structure, Aggregation and Biological Potency of Beef Insulin Cross-Linked at A1 and B29 by Diaminosuberic Acid G.G. Dodson, S. Cutfield, E. Hoenjet, A. Wollmer and D. Brandenburg Requires Authentication Unlicensed Licensed Download PDF	17
Correlation of Structural Details of Insulin in the Crystal and in Solution A. Vollmer, W. Straßburger, E. Hoenjet, U. Glatter, J. Fleischhauer, D.A. Mercola, R.A.G. de Graaf, E.J. Dodson, G.G. Dodson, D.G. Smith, D. Brandenburg and W. Danho Requires Authentication Unlicensed Licensed Download PDF	27
SECTION II. PEPTIDE SYNTHESIS
An Assessment of Protecting Group Strategies in Synthesis of Large Peptides J. Meienhofer Requires Authentication Unlicensed Licensed Download PDF	39
Fully Active Semisynthetic Insulin by Selective Formation of the Disulfide Bridges as an Intermediate Result of the Total Synthesis by Fragment Condensation on Polymer Phase C. Birr, R. Pipkorn, H.-G. Gattner, R. Renner and H.-U. Häring Requires Authentication Unlicensed Licensed Download PDF	51
[A14-Phenylalanine-Insulin]: A Synthetic Analogue W. Danho, A. Sasaki, E. Büllesbach, H.-G. Gattner and A. Wollmer Requires Authentication Unlicensed Licensed Download PDF	59
[B25-Tyrosine]B-Chain-S-Sulfonate of Porcine Insulin R. Knorr, W. Danho, E. Büllesbach, H.-G. Gattner and E. Zahn Requires Authentication Unlicensed Licensed Download PDF	67
The Synthesis of [B25-4-Nitrophenylalanine]-Octapeptide B(23-30) of Porcine Insulin M. Casaretto, W. Danho, Gattner and H. Zahn Requires Authentication Unlicensed Licensed Download PDF	73
A Novel Route for the Preparation of Mono-Iodotyrosine and Mono-Iodotyrosine-Containing Peptides by Electrochemical Reduction of Di-Iodo Derivatives H.-G. Gattner and W. Danho Requires Authentication Unlicensed Licensed Download PDF	77
Alternative Approach for Human Proinsulin Synthesis N. Yanaihara, M. Sakagami and C. Yanaihara Requires Authentication Unlicensed Licensed Download PDF	81
An Alternative Synthesis of Glucagon by the Method of Solid Phase Condensation of Peptide Fragments Y-T. Kung, D-Y. Zhu, X-D. Qiu, X-W. Yuan, L-T. Ke and W. Wei Requires Authentication Unlicensed Licensed Download PDF	91
SECTION III. SEMISYNTHESIS AND CHEMICAL MODIFICATION
Progress Towards the Semisynthesis of Preproinsulin V.K. Naithani, E.E. Büllesbach, H. Zahn, J. Shield, R. Chance and M.A. Root Requires Authentication Unlicensed Licensed Download PDF	99
Specific Activation of the Arginine Carboxyl Group of the B-Chain of Bovine Des-Octapeptide-(B23-30)-Insulin E. Canova-Davis and F.H. Carpenter Requires Authentication Unlicensed Licensed Download PDF	107
Enzyme-Catalyzed Semisynthesis with Insulin Derivatives H.-G. Gattner, W. Danho and V.K. Naithani Requires Authentication Unlicensed Licensed Download PDF	117
The Relative Reactivity of Insulin Amino Groups as an Indicator of Structural Accessibility and its Use for Synthetic Approaches for Structure-Function Studies H.-J. Friesen Requires Authentication Unlicensed Licensed Download PDF	125
A14-(N-Methylpyridinium) and A14-(2-Nitro-4-Trimethylammoniophenyl) Derivatives of Bovine Insulin S.E. Drewes, B.R.D. Easter, H.M. Robinson and H.E.M. Magojo Requires Authentication Unlicensed Licensed Download PDF	135
Preparation of Covalent Insulin Dimers A. Schüttler and D. Brandenburg Requires Authentication Unlicensed Licensed Download PDF	143
Reactions of Insulin Derivatives with ETAC Reagents R.G. Lawton Requires Authentication Unlicensed Licensed Download PDF	151
SECTION IV. RADIOACTIVE LABELLING AND SEPARATION TECHNIQUES
The Application of HPLC to the Analysis of Radio- Iodinated Tracers of Glucagon and Insulin J. Markussen and U.D. Larsen Requires Authentication Unlicensed Licensed Download PDF	161
Monoiodoinsulin Specifically Substituted in A14-Tyr or A19-Tyr B. Hansen, S. Linde, 0. Sonne and J. Gliemann Requires Authentication Unlicensed Licensed Download PDF	169
Preparation of Homogeneous Insulin Tracers with Monoand Di-Iodo-Desaminotyrosines in Position B1 S. Bahrami and D. Brandenburg Requires Authentication Unlicensed Licensed Download PDF	177
Insulin and Proteins Labeled by Microwave Discharge Activation of Tritium H. Tschesche, W. Behr and R. Wick Requires Authentication Unlicensed Licensed Download PDF	185
Radioactive Labelling (¹⁴ C, ³ H) of Insulin and Insulin Derivatives by Reductive Methylation; Isolation of Homogeneous N, N-Di-Methylated Derivatives J. Uschkoreit, D. Brandenburg and H.-J. Friesen Requires Authentication Unlicensed Licensed Download PDF	191
Quantitative Determination of Insulin by Gradient Elution HPLC M.E.F. Biemond, W.A. Sipman and J Olivié Requires Authentication Unlicensed Licensed Download PDF	201
Some Preliminary Findings in Isotachophoretic Analyses of Insulin A. Baldesten Requires Authentication Unlicensed Licensed Download PDF	207
Studies on the Denaturation of Dissolved Insulin H. Thurow Requires Authentication Unlicensed Licensed Download PDF	215
SECTION V. RECEPTORS AND HORMONE-RECEPTOR INTERACTION
¹²⁵ I-SpHPP-Avidin: A Tool for Hormone Receptor Studies F.M. Finn and K. Hofmann Requires Authentication Unlicensed Licensed Download PDF	225
Chromatographic Properties of the Adipocyte Transport System in Detergent Solution and its Resolution from the Insulin Receptor M.P. Czech, C. Carter-Su and P.F. Pilch Requires Authentication Unlicensed Licensed Download PDF	233
Hydrophobic Interaction Chromatography as a Tool in Insulin Receptor Purification L. Kuehn, H. Meyer and H. Reinauer Requires Authentication Unlicensed Licensed Download PDF	243
Localization of Insulin-Receptor Complexes on the Surface of Whole Cells by Autoradiography E. Junger, C. Giesen, M. Semmler, H. Reinauer and L. Bachmann Requires Authentication Unlicensed Licensed Download PDF	251
Insulin Receptors in the Heart Muscle: Evidence for the Negative Cooperativity Binding Model J. Eckel and H. Reinauer Requires Authentication Unlicensed Licensed Download PDF	259
Insulin Receptors, Insulin Degradation, and Biological Activity O. Sonne and J. Gliemann Requires Authentication Unlicensed Licensed Download PDF	263
Regulation of Insulin Receptors in Isolated Hepatocytes from Normal and Streptozotocin-Diabetic Rats in the Fed and 48 H Fasted State S. Gammeltoft, L.Ø.. Kristensen, M. Folke and L. Sestoft Requires Authentication Unlicensed Licensed Download PDF	271
Insulin-Receptor Turnover and Down Regulation S. Terris and D.F. Steiner Requires Authentication Unlicensed Licensed Download PDF	277
Receptor-Mediated Internalisation of Insulin, Glucagon and Growth Hormone in Intact Rat Liver. A Biochemical Study B. Desbuquois and M.-C. Postel-Vinay Requires Authentication Unlicensed Licensed Download PDF	285
Kinetics of Insulin Binding to Its Receptors in vivo. Effects of Fasting J.C. Sodoyez, F. Sodoyez-Goffaux and Y.M. Thiry-Moris Requires Authentication Unlicensed Licensed Download PDF	293
Hystricomorph Insulins and Insulin Receptors N.R. Lazarus, K. O’Connor, R.W.J. Neville, P. Goodwin, R. Horuk and D. Stone Requires Authentication Unlicensed Licensed Download PDF	301
SECTION VI. PHOTO-INDUCED HORMONE-RECEPTOR COUPLING
Photoreactive Insulin Derivatives: Preparation and Characterization P. Thamm, D. Saunders and D. Brandenburg Requires Authentication Unlicensed Licensed Download PDF	309
Photoreactive Insulin Derivatives: Chemical and Physical Properties D. Saunders, P. Thamm and D. Brandenburg Requires Authentication Unlicensed Licensed Download PDF	317
The Preparation and Application of an A1-Substituted Photo-Reactive Insulin Analogue A.R. Rees and M.R. Whittle Requires Authentication Unlicensed Licensed Download PDF	327
Photoaffinity Labeling of Insulin Receptor Proteins of Liver Plasma Membranes C.C. Yip, C.W.-T. Yeung and M.L. Moule Requires Authentication Unlicensed Licensed Download PDF	337
Characterisation of Insulin Binding Sites in Rat Liver Plasma Membranes Using Photoreactive Insulin Analogues M.H. Wisher, P. Thamm, D. Saunders, P.H. Sönksen and D. Brandenburg Requires Authentication Unlicensed Licensed Download PDF	345
Permanent Activation of Lipogenesis by Insulin Covalently Bound to Adipocyte Receptors C. Diaconescu, P. Thamm, D.J. Saunders and D. Brandenburg Requires Authentication Unlicensed Licensed Download PDF	353
SECTION VII. STRUCTURE, BINDING, ACTIVITY
The Activation of Adenylate Cyclase by Chemically Modified Forms of Glucagon and its Relationship to Receptor Binding R.M. Epand Requires Authentication Unlicensed Licensed Download PDF	363
Structure-Activity Relationships of Insulin-Induced Negative Cooperativity Among Receptor Sites M. Piron, M. Michiels-Place, M. Waelbroeok, P. De Meyts, A. Schüttler and D. Brandenburg Requires Authentication Unlicensed Licensed Download PDF	371
Properties of a Mutant Insulin Species Causing Human Diabetes J.M. Olefsky, M. Saekow, M. Kobayashi, O.G. Kolterman, H. Tager, B. Given, D. Baldwin, M. Mako, J. Markese, A.M. Hubenstein and H. Poucher Requires Authentication Unlicensed Licensed Download PDF	393
A1-Modified Insulins: Receptor Binding and Biological Activity P. Rösen, M. Simon, H. Reinauer, D. Brandenburg, H. -J. Friesen and C. Diaconescu Requires Authentication Unlicensed Licensed Download PDF	403
Biological Activity of Insulin Analogues Substituted at the Amino Group of B1-Phenylalanine R. Geiger, R. Obermeier, V. Teetz, R. Uhmann, H.D. Summ, H. Neubauer, K. Geisen and G. Regitz Requires Authentication Unlicensed Licensed Download PDF	409
Functional Role of the N-Terminal Region of the B-Chain of Insulin C. W.-T. Yeung, M.L. Moule and C.C. Sip Requires Authentication Unlicensed Licensed Download PDF	417
Biological Properties of Covalent Insulin Dimers K.P. Willey, M.A. Tatnell, R.H. Jones, A. Schüttler and D. Brandenburg Requires Authentication Unlicensed Licensed Download PDF	425
Biological Activity and Receptor Binding of Six Different Covalent Dimers of Insulin K. Schlüter, K.-G. Petersen, A. Schüttler, D. Brandenburg and L . Kerp Requires Authentication Unlicensed Licensed Download PDF	433
In vitro and in vivo Effects of Poly-N-Vinylpyrrolidone- Insulin H.J. Kolb, R. Renner, B.U. von Specht and K.D. Hepp Requires Authentication Unlicensed Licensed Download PDF	439
Study of Insulin Action by Use of Insulin-Dextran Complex: Uptake of Insulin into Subcellular Fractions and Stimulation of Pyruvate Dehydrogenase in Mouse Adipocytes Y. Sakamoto and T. Kuzuya Requires Authentication Unlicensed Licensed Download PDF	447
Studies on the Mechanism of Insulin Action VI: The Interaction of Insulin Fragments with Insulin Receptor Y-M Feng, J-L. Gu, X-T. Zhang, Z-X. Lu, W-J. Xu and J-H Zhu Requires Authentication Unlicensed Licensed Download PDF	455
Stimulation of Intracellular H₂ 0₂ Production in Rat Epididymal Adipocytes by Insulin, Insulin Fragments, and Other Hormones and Growth Factors with Insulin-Like Activities C. de Haën, D.B. Muchmore and S.A. Little Requires Authentication Unlicensed Licensed Download PDF	461
Early Events in Insulin Binding and Insulin Action in Fat Cells and Hepatocytes H. Häring, D.G. Brocks, E.A. Siess and W. Kemmler Requires Authentication Unlicensed Licensed Download PDF	469
Role of the Biodegradation Process in the Action of Insulin. A Proposal for a Model Consisting of Sulfhydryl- Disulfide Interchange Reaction and Proteolysis P.T. Varandani Requires Authentication Unlicensed Licensed Download PDF	475
Insulin Receptors, Receptor Antibodies and the Mechanism of Insulin Action C.R. Kahn, C. Grunfeld, G.L. King, E. Van Obberghen and K.L. Baird Requires Authentication Unlicensed Licensed Download PDF	483
SECTION VIII. DEGRADATION
Studies on Uptake of [³ H]-Insulin by Erythrocytes W. Behr and H. Tsohesahe Requires Authentication Unlicensed Licensed Download PDF	495
An Insulin-Degrading Enzyme from Human Erythrocytes: Isolation and Characterization H.J. Kolb and E. Standl Requires Authentication Unlicensed Licensed Download PDF	501
Comparison of¹²⁵I-Insulin and [B1- 3 H-Phenylalanine]- Insulin Degradation by Insulin Protease W.C. Duckworth and P.A. Halban Requires Authentication Unlicensed Licensed Download PDF	509
The Chemical Characterization of the Products of the Processing of Subcutaneously Injected Insulin J.G. Davies, R.E. Offord, P.A. Halban and M. Berger Requires Authentication Unlicensed Licensed Download PDF	517
Some Inhibitors of Insulin Degradation R.E. Offord, J. Philippe, S.M. Hoare, P.A. Halban and M. Berger Requires Authentication Unlicensed Licensed Download PDF	525
Excretion of Endogenous and Exogenous Insulin by Kidney in Diabetic Ketoacidosis H.S. Sacks, F.B. Stenz and A.E. Kitabohi Requires Authentication Unlicensed Licensed Download PDF	531
Incubation of Insulin in Hyperglycemic Blood Generates Insulin Dimers T.R. Csorba, M.M. Cannon, M. Ungar and N.S. Track Requires Authentication Unlicensed Licensed Download PDF	539
SECTION IX. IMMUNOLOGY
Genetic Regulation of the Immune Response of Mice to Insulins of Different Species K. Keck and M. Momayezi Requires Authentication Unlicensed Licensed Download PDF	551
Genetic Control of the Immune Response to Insulin A.S. Rosenthal, J.W. Thomas, J. Schroer, W. Danho, E. Büllesbach and J. Föhles Requires Authentication Unlicensed Licensed Download PDF	559
Analysis of the Immunogenicity of Three Insulin- Preparations U. Kiesel, F.K. Jansen, D. Brandenburg and H.-G. Gattner Requires Authentication Unlicensed Licensed Download PDF	569
Studies on the Immunological Properties of Natural and Modified Insulins H.P. Neubauer and H.H. Schöne Requires Authentication Unlicensed Licensed Download PDF	575
Genetic Control of the Immune Response to Insulin: A Clinical Study of Adverse Immunologic Reactions to Insulin A.S. Rosenthal, J.T. Blake, C.R. Kahn, D. Mann and J. Galloway Requires Authentication Unlicensed Licensed Download PDF	585
The Induction of Hyperglycemia with Insulin Antibodies to B-Chain Determinants E.R. Arquilla, J.M. Kelso, I.Y. Tamai and M.D. Roth Requires Authentication Unlicensed Licensed Download PDF	593
The Pattern of B-Lymphocyte Specificities for Modified and Unmodified Insulins in the Mouse U. Kiesel and H-G. Gattner Requires Authentication Unlicensed Licensed Download PDF	603
Specificity of Rabbit Anti-Insulin Antibody K. Keck, K. Jäger, R. Geiger, D. Brandenburg and H.-G. Gattner Requires Authentication Unlicensed Licensed Download PDF	611
Radioimmunoassay of Chemically-Modified Insulins - Use and Misuse J.H. Thomas, D.I. Dron, R.H. Jones, P.H. Sönksen and D. Brandenburg Requires Authentication Unlicensed Licensed Download PDF	619
Purity of Chromatographycally Purified Insulins Measured by Skin-Reactivity and Insulin-Specific IGE H.-G. Velcovsky, E. Mäser and K. Federlin Requires Authentication Unlicensed Licensed Download PDF	627
SECTION X. BIOSYNTHESIS, STORAGE, EVOLUTION
Human Preproinsulin: Primary Structure of the Messenger RNA A. Ullrich, D.V. Goeddel, A. Gray and I. Sures Requires Authentication Unlicensed Licensed Download PDF	637
Quantification of Proinsulin Biosynthesis by Determination of Specific Radioactivity of [³ H]-Leucine in Pancreatic Islets S. Schmidt, D. Schröder, H. Jahr and H. Zühlke Requires Authentication Unlicensed Licensed Download PDF	643
Immunoreactive Rat C-Peptides I and II in Glucose Perfusate of Isolated Pancreas C. Yanaihara, J. Ozaki, N. Nishida, N. Yanaihara and T. Keneko Requires Authentication Unlicensed Licensed Download PDF	651
Biosynthesis of Somatostatin in Pancreatic Islets of Wistar Rats S. Schmidt, H. Zühlke, D. Schröder, M. Ziegler and H. Jahr Requires Authentication Unlicensed Licensed Download PDF	659
Crystallography of Intracellular Insulin and Glucagon as Revealed by Investigations of Tissues and Models R.H. Lange Requires Authentication Unlicensed Licensed Download PDF	665
Pancreatic Hormone Storage Granules: The Role of Metal Ions and Polypeptide Oligomers J.E. Pitts, S.P. Wood, R. Horuk, S. Bedarkav and T.L. Blundell Requires Authentication Unlicensed Licensed Download PDF	673
On the Molecular Biology of Hagfish Insulin S.O. Emdin and S. Falkmer Requires Authentication Unlicensed Licensed Download PDF	683
SECTION XI. INSULIN-RELATED HORMONES
Possible Relationships in the Processing, Storage and Secretion of Some Insulin-Related Peptides G.G. Dodson, N. Isaacs, R.A. Bradshaw and H.D. Niall Requires Authentication Unlicensed Licensed Download PDF	695
Insulin-Like Growth Factors R.E. Humbel, R. Andres, C. Ernest, G. Haselbacher, E. Rinderknecht, E.R. Froesch, J. Schwander, H. Walter and J. Zapf Requires Authentication Unlicensed Licensed Download PDF	703
Relaxin and Relaxin-Like Peptides in Ovaries of Pregnant Sows and Sharks C. Schwabe Requires Authentication Unlicensed Licensed Download PDF	709
Structural Studies on Porcine Relaxins and their Biosynthetic Precursors H.D. Niall, M. John, R. James, S. Kwok, R. Mercado, G. Bryant-Greenwood, R.A. Bradshaw, M. Gast and I. Boime Requires Authentication Unlicensed Licensed Download PDF	719
PRESENTATIONS NOT INCLUDED IN THIS VOLUME Requires Authentication Unlicensed Licensed Download PDF	727
LIST OF PARTICIPANTS Requires Authentication Unlicensed Licensed Download PDF	729
ABBREVIATIONS Requires Authentication Unlicensed Licensed Download PDF	735
SUBJECT INDEX Requires Authentication Unlicensed Licensed Download PDF	739
AUTHOR INDEX Requires Authentication Unlicensed Licensed Download PDF	749

Language: English
Publisher: De Gruyter
Edition: Reprint 2019
Pages
- Front matter: 18
- Main content: 752
Illustrations
- Other: Num. figs.
Keywords: Insulin

eBook

Published: May 20, 2019
ISBN: 9783111646190

Hardcover

Published: April 1, 1980
ISBN: 9783110081565