Vitamin D: A Pluripotent Steroid Hormone: Structural Studies, Molecular Endocrinology and Clinical Applications. Proceedings of the Ninth Workshop on Vitamin D, Orlando, Florida, USA, May 28–June 2, 1994

Published by De Gruyter 1994

Vitamin D

A Pluripotent Steroid Hormone: Structural Studies, Molecular Endocrinology and Clinical Applications. Proceedings of the Ninth Workshop on Vitamin D, Orlando, Florida, USA, May 28–June 2, 1994

Edited by: Anthony W. Norman , Roger Bouillon and Monique Thomasset

https://doi.org/10.1515/9783110882513

Contents

Frontmatter Publicly Available Download PDF	I
FOREWORD Publicly Available Download PDF	V
Official Sponsors and Donors NINTH WORKSHOP ON VITAMIN D Publicly Available Download PDF	IX
YOUNG INVESTIGATOR AWARDEES NINTH WORKSHOP ON VITAMIN D Publicly Available Download PDF	X
Vitamin D Workshop. Career Recognition Awardees Publicly Available Download PDF	XI
Contents Publicly Available Download PDF	XIII
Chemistry of Vitamin D
Shape and Conformation of Vitamin D. 11-Fluoro-1a-Hydroxyvitamin D₃: The Quest for Experimental Evidence of the Folded Vitamin D Conformation P. J. de Clercq, G.-D. Zhu, D. van Haver and H. Jurriaans Requires Authentication Unlicensed Licensed Download PDF	1
Conformation and Related Topological Features of Vitamin D: Structure-Function Relationships W. H. Okamura, M. M. Midland, M. W. Hammond, N. Abd. Rahman, M. C. Dormanen, I. Nemere and A. W. Norman Requires Authentication Unlicensed Licensed Download PDF	12
Chemical Conversion of Vitamin D₃ to Calcitriol Lactone G. Pizzolato, P. M. Wovkulich, M. R. Uskokovic and A. Norman Requires Authentication Unlicensed Licensed Download PDF	21
Design, Synthesis, and SAR of Some 1-Substituted A-Ring Analogs of Calcitriol G. H. Posner Requires Authentication Unlicensed Licensed Download PDF	25
A General Synthetic Route to A-Ring Hydroxylated Vitamin D Analogs from D-Pentoses R. M. Moriarty, J. Kim and H. Brumer Requires Authentication Unlicensed Licensed Download PDF	27
Retiferols. Design and Synthesis of the New Class of Vitamin D Analogs A. Kutner, H. Zhao, A. Podosenin, H. Fitak, M. Chodynski, S. J. Halkes and S. R. Wilson Requires Authentication Unlicensed Licensed Download PDF	29
Introduction of 1a-Hydroxyl Group to Provitamin D Causes New Photoisomerization Reactions S. Yamada, H. Ishizaka, H. Ishida and K. Yamamoto Requires Authentication Unlicensed Licensed Download PDF	31
Synthesis and Determination of the Configurations of the 23-Hydroxylated Metabolites of Calcipotriol (MC 903) and their Epimers M. J. Calverley Requires Authentication Unlicensed Licensed Download PDF	33
Syntheses of Potential Inhibitors of 25-Hydroxyvitamin D₃-1a-Hydroxylase: A-Ring Analogs D. Daniel and W. H. Okamura Requires Authentication Unlicensed Licensed Download PDF	35
Metallic Complexes of Hydroxylated Derivatives of Vitamin D₃ X. T. Do, A.-S. Coquin, S. Megdad, M. A. Khan and G. Bouet Requires Authentication Unlicensed Licensed Download PDF	37
A New Route to the Lythgoe-Roche's A-Ring Precursor of 1a,25-Dihydroxyvitamin D₃ M. Torneiro, S. Vrielynck, A. M. Garcia, J. L. MascareHas, L. Castedo and A. Mourino Requires Authentication Unlicensed Licensed Download PDF	39
Structure-Activity Studies of Fluorinated Vitamin D Analogs K. Iseki, Y. Tanaka, M. Kawai, S. Unten, N. Ikekawa and Y. Kobayashi Requires Authentication Unlicensed Licensed Download PDF	41
An In Vitro Model of Previtamin D Photosynthesis as Possible Monitor of Ozone Depletion I. Terenetskaya Requires Authentication Unlicensed Licensed Download PDF	43
Synthesis of 24-Hydroxy-Vitamin D Analogues J. Granja, M. Rey, J. A. Martinez, A. Fernandez, L. Castedo and A. Mouriflo Requires Authentication Unlicensed Licensed Download PDF	45
Chromatographic Isolation and Spectroscopic Characterization of the Photoisomers of 1a,25-Dihydroxy-Provitamin D₃ S. Gliesing, M. Reichenbcher, M. Gonschior, F. Ude, C. Lange and B. Schdnecker Requires Authentication Unlicensed Licensed Download PDF	47
A New Route to the Vitamin D Triene System J. L. Mascarenas, A. M. Garcia, C. Varela, L. Castedo and A. Mourino Requires Authentication Unlicensed Licensed Download PDF	49
Studies on the Synthesis of 19-Norprevitamin D₃ Analogues M. Maestro, L. Sarandeses, R. Riveiros, L. Castedo and A. Mourino Requires Authentication Unlicensed Licensed Download PDF	51
Structure/Function Studies of Vitamin D Steroids
The Need for New Vitamin D Analogues: Mechanisms of Action and Clinical Applications L. Binderup, C. Carlberg, A.-M. Kissmeyer, S. Latini, I. S. Mathiasen and C. Mork Hansen Requires Authentication Unlicensed Licensed Download PDF	55
Future Prospects for Vitamin D Analogs Y. Nishii, N. Kubodera, K. Sato and K. Kumaki Requires Authentication Unlicensed Licensed Download PDF	64
Chemistry and Biology of 22,23-yne Analogs of Calcitriol C. Bretting, C. Mark Hansen and N. Rastrup Andersen Requires Authentication Unlicensed Licensed Download PDF	73
Chemistry and Biology of 23-oxa-aro- and 23-thia-aro-Vitamin D Analogues with High Antiproliferative and Low Calcemic Activity G. Grue-Sorensen, E. Binderup and L. Binderup Requires Authentication Unlicensed Licensed Download PDF	75
Activity of Vitamin D Analogs in Co-Transfected COS-7 Cells H. van Baelen, R. Convents and R. Bouillon Requires Authentication Unlicensed Licensed Download PDF	77
Synthesis and Biological Character of 1β-Hydroxylated Vitamin D₃ Analogs N. Kubodera, Y. Ono, H. Watanabe, A. Kawase, T. Okano, N. Tsugawa and T. Kobayashi Requires Authentication Unlicensed Licensed Download PDF	79
Biological Activity and Conformational Analysis of 1β,25-Dihydroxyvitamin D₃ and its Analogues T. Okano, N. Tsugawa, S. Masuda, A. Takeuchi, T. Kobayashi, N. Kubodera, K. Sato, N. Johnson, G. H. Posner and Y. Nishii Requires Authentication Unlicensed Licensed Download PDF	81
Topological Mimics of the 6-s-cis-Conformer of 1a,25-Dihydroxyvitamin D₃ Based on the Provitamin D Skeleton M. W. Hammond, A. W. Norman, J. E. Bishop, M. C. Dormanen and W. H. Okamura Requires Authentication Unlicensed Licensed Download PDF	83
Chemistry and Biology of Highly Active 22-oxy Analogs of 20-epi Calcitriol with Very Low Binding Affinity to the Vitamin D Recepto M. J. Calverley, G. Grue-Sorensen, C. Bretting and L. Binderup Requires Authentication Unlicensed Licensed Download PDF	85
New Discoveries in Vitamin D Related Compounds H. Zhao, A. Kutner, A. Podosenin and S. R. Wilson Requires Authentication Unlicensed Licensed Download PDF	87
Modelling of Previtamin D Photosynthesis in View of its Conformational Flexibility O. G. Dmitrenko and I. P. Terenetskaya Requires Authentication Unlicensed Licensed Download PDF	89
Active Vitamin D Analogs with Side Chain Hydroxyl Group Occupying Diverse Spatial Region K. Yamamoto, S. Yamada and M. Ohta Requires Authentication Unlicensed Licensed Download PDF	91
Synthesis and Biological Activity of 23-oxa Vitamin D Analogues A. Steinmeyer, M. Haberey, G. Kirsch, G. Neef, K. Schwarz, R. Thieroff-Ekerdt and H. Wiesinger Requires Authentication Unlicensed Licensed Download PDF	93
Synthesis and Biological Activity of 20-Hydroxylated Vitamin D Analogues K. Hansen and C. Merk Hansen Requires Authentication Unlicensed Licensed Download PDF	95
20-Methyl Vitamin D Analogues G. Neef, G. Kirsch, K. Schwarz, H. Wiesinger, A. Menrad, M. Fähnrich, R. Thieroff-Ekerdt and A. Steinmeyer Requires Authentication Unlicensed Licensed Download PDF	97
2β-Substituted Calcitriols and Other A-Ring Substituted Analogues - Synthesis and Biological Results B. Schönecker, M. Reichenbächer, S. Gliesing, R. Prousa, S. Wittmann, S. Breiter, R. Thieroff-Ekerdt, H. Wiesinger, M. Haberey, D. Scheddin and H. Mayer Requires Authentication Unlicensed Licensed Download PDF	99
Syntheses and Biological Activity of 1ß-Substituted Active Vitamin D₃ Analogs H. Ishida, M. Shimizu, K. Yamamoto, K. Yamaguchi and S. Yamada Requires Authentication Unlicensed Licensed Download PDF	101
Vitamin D Binding Protein
Probing the Vitamin D-Sterol Binding Domain of Human Vitamin D-Binding Protein: Chemical Modification of Specific Amino Acid Residues N. Swamy and R. Ray Requires Authentication Unlicensed Licensed Download PDF	105
Crystallization and Preliminary X-Ray Investigation of Vitamin D-Binding Protein from Human Serum C. Verboven, H. de Bondt, C. de Ranter, R. Bouillon and H. van Baelen Requires Authentication Unlicensed Licensed Download PDF	107
Effects of Vitamin D-Binding Proteins on Biological Functions of 1 a,25-Dihydroxyvitamin D₃ Analogues S. Ishizuka, A. Honda, Y. Mori, N. Kurihara, J. Tatsumi, K. Anai, K. Ikeda and A. W. Norman Requires Authentication Unlicensed Licensed Download PDF	109
Vitamin D Hydroxylases: Biochemistry and Regulation
Differences of the Regulation of 24-Hydroxylase Gene Expression in the Kidney and Intestine T. Suda, K. Lida, Y. Ohyama, K. Ozono, M. Uchida, S. Kato and T. Shinki Requires Authentication Unlicensed Licensed Download PDF	113
Regulation of the Ferredoxin Component of Renal Hydroxylases at the Transcriptional and Postradiational Level and of the Protein Inhibitor of Cyclic AMP-Dependent Kinase H. L. Henry, C. Tang, R. Blanchard and G. S. Marchetto Requires Authentication Unlicensed Licensed Download PDF	122
Site and Rate of Hydroxylation of 1a-OH-D₃ Analogs by CYP27 Not Altered by Increasing Length or Changing Orientation of Vitamin D₃ Side Chain F. J. Dilworth, S. Strugnell, Y.-D. Guo, M. J. Calverley, H. L. J. Makin and G. Jones Requires Authentication Unlicensed Licensed Download PDF	131
Protein Kinase C Up-Regulates 1 a,25-Dihydroxyvitamin D₃-Induced Expression of 24-Hydroxylase Gene T. Shinki, M. Namiki, M. Uchida, K. Ozono, Y. Ohyama and T. Suda Requires Authentication Unlicensed Licensed Download PDF	133
IGF-I Restores the Age-Related Defect in Renal 1,25(OH)₂D₃ Biosynthesis in Response to Dietary Phosphorus Restriction in Rats M.-S. Wong, V. Tembe and M. J. Favus Requires Authentication Unlicensed Licensed Download PDF	135
In Vitro Production of 1,25-Dihydroxyvitamin D₃ by Cultured Mouse Kidney Cells and its Regulation by Extracellular Phosphate and IGF-1 C. Menaa, F. Vrtovsnik, G. Friedlander and M. Garabedian Requires Authentication Unlicensed Licensed Download PDF	137
The Cytochromes P450 Catalyzing 25-Hydroxylation of Vitamin D and la-Hydroxy lation of 25-Hydroxyvitamin D₃ in Pig Liver E. Axen, H. Postlind, H. Sjöberg and K. Wikvall Requires Authentication Unlicensed Licensed Download PDF	139
Evidence that 1a - and 27-Hydroxylation of 25-Hydroxyvitamin D₃ are Catalyzed by CYP27 in Pig Kidney Mitochondria H. Postlind Requires Authentication Unlicensed Licensed Download PDF	141
The Kinetics of Monocyte la-Hydroxy läse in Uremia. Modulation by Calcitriol and 25(OH)D₃ Therapy A. Dusso, M. Gallieni, S. Kamimura, A. Ahmed and E. Slatopolsky Requires Authentication Unlicensed Licensed Download PDF	143
Eicosanoid Inhibitor and Cytokine Regulation of 1,25(OH)₂D₃ Synthesis in Synovial Fluid Macrophages from Patients with Inflammatory Arthritis S. J. Fowler, J. Y. Yuan, A. J. Freemont, E. B. Mower and M. E. Hayes Requires Authentication Unlicensed Licensed Download PDF	145
25-Hydroxyvitamin D-la-Hydroxy läse is Responsible for the Synthesis of 1.25-Dihydroxyvitamin D₃ by Peritoneal Macrophages of CAPD Treated Uremic Patients S. Shany, I. Zuili, N. Yankowitz and C. Chaimovitz Requires Authentication Unlicensed Licensed Download PDF	147
Influence of Extracellular Calcium in the Kinetic Behaviour of 1-Hydroxylase (1-OHase) and 24-Hydroxylase (24-OHase) in Walker Carcinosarcoma 256 Cells (WS) and in the Renal Proximal Tube Phenotype Cells (LLC-PK1) M. J. Municio and M. L. Traba Requires Authentication Unlicensed Licensed Download PDF	149
Insulin and Calcitonin Decrease the Expression of the Renal 25(OH)D-24- Hydroxylase Cytochrome P450 in Diabetic Rats N. Wongsurawat, M. A. Boltz, R. Nemani and H. J. Armbrecht Requires Authentication Unlicensed Licensed Download PDF	151
Continuous Activation of 25-Hydroxyvitamin D₃-24-Hydroxylase mRNA Expression by 1a,25-Dihydroxyvitamin D₃-3ß-Bromoacetate M. L. Chen, R. Ray, G. Heinrich, Y.-J. Ohyama, K. Okuda and M. F. Holick Requires Authentication Unlicensed Licensed Download PDF	153
Regulation of 24-Hydroxylase mRNA Expression by 1a,25(OH)₂D₃ and its Fluorinated Analogues Y. Miyamoto, T. Shinki, M. Namiki, Y. Ohyama, T. Kasama, T. Sato and T. Suda Requires Authentication Unlicensed Licensed Download PDF	155
Comparative Effects of 1,25-Dihydroxyvitamin D₃ and EB 1089 on Murine 25-Hydroxyvitamin D₃-24-Hydroxylase S. Roy, J. Martel, O. Chahal and H. S. Tenenhouse Requires Authentication Unlicensed Licensed Download PDF	157
Vitamin D Metabolism and Catabolism
Target Cell Metabolism of Vitamin D and its Analogs G. Jones, D. Lohnes, S. Strugnell, Y.-D. Guo, S. Masuda, V. Byford, H. L. J. Makin and M. J. Calverley Requires Authentication Unlicensed Licensed Download PDF	161
In Vivo Regulation of Rat Intestinal 24-Hydroxylase (I-24-OHase): Potential New Role of Calcitonin M. J. Beckman, J. P. Goff, T. A. Reinhardt, D. C. Beitz and R. L. Horst Requires Authentication Unlicensed Licensed Download PDF	170
Metabolism of 1a,25-Dihydroxyvitamin D₃ and One of its A-Ring Diastereomer 1a,25-Dihydroxy-3-Epivitamin D₃ in Neonatal Human Keratinocytes G. S. Reddy, K. R. Muralidharan, W. H. Okamura, K.-Y. Tserng and J. A. McLane Requires Authentication Unlicensed Licensed Download PDF	172
Vitamin D Metabolism in Human Colon Adenocarcinoma-Derived Caco-2 Cells H. S. Cross, M. Peterlik, H. Egger and I. Schuster Requires Authentication Unlicensed Licensed Download PDF	174
Studies on Vitamin D Metabolism by a Human Small Cell Lung Cancer (SCLC) Cell Line, NCI-H82 S. E. Heys, M. E. Hayes and E. B. Mawer Requires Authentication Unlicensed Licensed Download PDF	176
The In Vitro Metabolism of Calcipotriol, 1,24(OH)₂D₃ and 1,25(OH)₂D₃ A.-M. Kissmeyer and L. Binderup Requires Authentication Unlicensed Licensed Download PDF	178
Regulation of Tissue Inhibitor of Metalloproteinases (TIMP) by 1,25- and 24,25- Dihydroxyvitamin D₃ in the Rat Growth Plate D. D. Dean, D. S. Howell, O. E. Muniz, G. A. Howard, B. A. Roos, Z. Schwartz, B. D. Boyan and R. Grumbles Requires Authentication Unlicensed Licensed Download PDF	180
The Effect of Parathyroid Hormone on Renal 24-Hydroxylase Activity in the Isolated Perfused Rat Kidney B. R. Thomas Requires Authentication Unlicensed Licensed Download PDF	182
Steroidal Hormones as Modulators of Vitamin D Metabolism in Human Keratinocytes L. Schuster, G. Herzig and G. Vorisek Requires Authentication Unlicensed Licensed Download PDF	184
Potentialisation of Vitamin D (Analogs) by Cytochrome P-450 Enzyme Inhibitors is Analog- and Cell-type Specific J. Zhao, S. Marcelis, B. K. Tan, A. Verstuyf and R. Bouillon Requires Authentication Unlicensed Licensed Download PDF	186
Novel Cleavage of Vitamin D₂ Side Chain During Catabolism by Keratinocyte Cell Line G. Jones, V. Byford, R. Kremer, H. L. J. Makin, J. C. Knutson and C. W. Bishop Requires Authentication Unlicensed Licensed Download PDF	188
22-Oxacalcitriol is Metabolized to C₂₁ Side-Chain-Cleaved Products in Both Liver and Target Cells S. Masuda, V. Byford, H. L. J. Makin, R. Kremer, T. Okano, T. Kobayashi, N. Kubodera, Y. Nishii and G. Jones Requires Authentication Unlicensed Licensed Download PDF	190
Metabolism of the 1a,25(OH)₂D₃ Analog 1a,25(OH)₂-16-ene-23-yne-D₃ in BALB/c Leukemic Mice and WEHI-3 Myeloid Leukemia Cells D. P. Satchell and A. W. Norman Requires Authentication Unlicensed Licensed Download PDF	192
Microtubules Mediate Cellular 25(OH)D₃ Traffic and the Response to 1,25(OH)₂D₃ in Human Monocytes S. Kamimura, M. Gallieni, E. Slatopolsky and A. Dusso Requires Authentication Unlicensed Licensed Download PDF	194
Study of the Metabolism of 1,25-Dihydroxy-16-ene-Vitamin D₃ in Rat Kidney Using On-line HPLC-Electrospray Tandem Mass Spectrometry B. Yeung, P. Vouros, M.-L. Siu-Caldera and G. S. Reddy Requires Authentication Unlicensed Licensed Download PDF	196
Human Placental Explants: An Efficient In Vitro Model for Comparative Metabolism of 1,25(OH)₂D₃ and its Synthetic Analogs N. L. Gelardi and G. S. Reddy Requires Authentication Unlicensed Licensed Download PDF	198
24,25(OH)₂D₃ Modulates 1,25(OH)₂D₃ Metabolism in Human Osteoblasts M.-L. Siu-Caldera, L. Zou, M. Ehrlich and G. S. Reddy Requires Authentication Unlicensed Licensed Download PDF	200
Metabolism of 25 Hydroxy Vitamin D₃: Kinetics of 23 and 24 Hydroxylases in Human Term Placenta S. J. Kang, N. Gelardi, L. P. Rubin, E. E. Delvin and G. S. Reddy Requires Authentication Unlicensed Licensed Download PDF	202
Comparative Study in Vitamin D Metabolism from the View-Point of Ontogeny and Phylogeny A. Takeuchi, T. Okano, H. Sekimoto, Y. Ishida and T. Kobayashi Requires Authentication Unlicensed Licensed Download PDF	204
Receptors for 1a,25(OH)₂D₃
Receptor Mediated Genomic Actions of 1,25(OH)₂D₃: Modulation by Phosphorylation M. R. Haussler, P. W. Jurutka, J.-C. Hsieh, P. D. Thompson, S. H. Selznick, C. A. Haussler and G. K. Whitfield Requires Authentication Unlicensed Licensed Download PDF	209
Modulation of Vitamin D₃ Target Gene Selectivity by Receptor Dimerization L. P. Freedman, B. Cheskis, B. Lemon, M. Liu and T. L. Towers Requires Authentication Unlicensed Licensed Download PDF	217
The Molecular Basis for the Genomic Actions of the Vitamin D₃ Hormone J. W. Pike Requires Authentication Unlicensed Licensed Download PDF	226
Expression of RXRa in Human Leukemic Cells During Differentiation Induced by All-Trans Retinoic Acid and 1a,25-Dihydroxyvitamin D H. Defacque, T. Commes, D. Pariente, C. Sevilla and J. Marti Requires Authentication Unlicensed Licensed Download PDF	235
Differential Activation of the Vitamin D Receptor (VDR) by 1,25(OH)2- Vitamin D₃ and its 20-Epimers S. Peleg, M. Sastry, E. Collins, J. Bishop and A. W. Norman Requires Authentication Unlicensed Licensed Download PDF	237
Dopamine Activates Vitamin D Receptor But Not Retinoid Receptor Mediated Transcription T. Matkovits and S. Christakos Requires Authentication Unlicensed Licensed Download PDF	239
Ordered Binding of Human Vitamin D and Retinoid-X Receptor Complexes to Asymmetric Vitamin D-Responsive Elements C. H. Jin and J. W. Pike Requires Authentication Unlicensed Licensed Download PDF	241
Immunohistochemical Localization of 1,25-Dihydroxy vitamin D₃ [1,25(OH)₂D₃] Receptors (VDR) in Human and Rat Pancreas J. A. Johnson, J. P. Grande, P. C. Roche and R. Kumar Requires Authentication Unlicensed Licensed Download PDF	243
Structure-Function Relationship of Human Parathyroid Hormone on Vitamin D Receptor Regulation in Osteoblast-Like Cells (ROS 17/2.8) S. Sriussadaporn, J. F. Whitfield, V. Tembe and M. J. Favus Requires Authentication Unlicensed Licensed Download PDF	245
Insulin-Like Growth Factor I Up-Regulates Intestinal 1,25(OH)₂D₃ Receptor in Phosphorus Restricted Rats S. Sriussadaporn, M. Wong, V. Tembe and M. J. Favus Requires Authentication Unlicensed Licensed Download PDF	247
A Peptide C-Terminal to the Second Zn-Finger of Human Vitamin D Receptor is Able to Specify Nuclear Localization Z. Luo and P. H. Maenpad Requires Authentication Unlicensed Licensed Download PDF	249
Molecular Cloning and Sequencing of a Novel cDNA Related to the Steroid/Thyroid/Vitamin Family of Nuclear Receptors from a Vitamin DDeficient Chick Intestinal cDNA Library E. D. Collins and A. W. Norman Requires Authentication Unlicensed Licensed Download PDF	251
Isolation and Analysis of cDNA Encoding a Naturally-Occurring Truncated Form of the Human Vitamin D Receptor L. Sturzenbecker, B. Scardaville, C. Kratzeisen, M. Katz, P. Abarzua, J. Omdahl and J. McLane Requires Authentication Unlicensed Licensed Download PDF	253
EB 1089, a Vitamin D Analogue, Induces the Vitamin D Receptor to Form Selective Receptor Complexes Depending on Cell Type I. S. Mathiasen, A. G. Mackay, K. W. Colston and L. Binderup Requires Authentication Unlicensed Licensed Download PDF	255
Gene Regulation
1,25(OH)₂D₃ Response Elements: Is There an Order? M. B. Demay, H. M. Kronenberg, J. L. Heymont, C. E. Bogado and S. L. Mackey Requires Authentication Unlicensed Licensed Download PDF	259
Vitamin D Regulation of Osteocalcin Gene Transcription: A Model for Defining Molecular Mechanisms of 1,25(OH)₂D₃ Control of Osteoblast Growth and Differentiation J. B. Lion, G. S. Stein, J. L. Stein, A. van Wijnen, M. Montecino, R. Desai, A. R. Shakoori, E. Breen, H. Hoffinan and S. M. Pockwinse Requires Authentication Unlicensed Licensed Download PDF	264
Regulation of Integrin Expression by 1,25 Dihydroxyvitamin D₃ F. P. Ross, X. Cao, H. Mimura, M. Chiba and S. L. Teitelbaum Requires Authentication Unlicensed Licensed Download PDF	273
Identification of a Chicken Intestinal DNA Binding Activity Not Related to the Vitamin D Receptor, but Capable of Specific Binding to Vitamin D Response Elements S. Ferrari, R. Battini and S. Molinari Requires Authentication Unlicensed Licensed Download PDF	282
Transcriptional Regulation of the Avian Mitochondrial Genome by Altered Dietary Vitamin D₃ Status: A Comparison of Intestinal and Kidney Responses S. S. Hannah, S. Y. Chou, K. E. Lowe, R. R. Zielinski, H. L. Henry and A. W. Norman Requires Authentication Unlicensed Licensed Download PDF	284
A Novel Vitamin D Response Element in the Murine c-fos Promoter R. St. Amaud and G. A. Candeliere Requires Authentication Unlicensed Licensed Download PDF	286
1,25(OH)₂-Vitamin D3 (D3) Interactions with 3,5,3'-Triiodothyronine (T3) Signaling in 3 Osteosarcoma Cell Lines G. R. Williams, R. Bland and M. C. Sheppard Requires Authentication Unlicensed Licensed Download PDF	288
1,25(OH)₂-Vitamin D₃ (D₃) Signaling in HT-29 Cells: Interactions with 9-eis Retinoic Acid (9-eis RA) K. F. Kane, M. J. S. Langman and G. R. Williams Requires Authentication Unlicensed Licensed Download PDF	290
Protein Inhibitor of Cyclic AMP-Dependent Protein Kinase: Genomic Cloning of a 1,25(OH)₂D₃ Down-Regulated Protein M. Rowland-Goldsmith and H. L. Henry Requires Authentication Unlicensed Licensed Download PDF	292
Lack of 9-eis Retinoic Acid Effect on Renal 24-Hydroxylase mRNA Expression by 1,25-Dihydroxyvitamin D₃ In Vivo T. A. Reinhardt and R. L. Horst Requires Authentication Unlicensed Licensed Download PDF	294
Regulation of Osteopontin Expression by Calcitriol in Mouse Epidermal JB6 Cells P.-L. Chang, T.-F. Lee, A. L. Ridall and C. W. Prince Requires Authentication Unlicensed Licensed Download PDF	296
Dissociation between Regulation of Growth and C-myc Oncogen Expression by Vitamin D in Caco-2 Cells W. Hulla, E. Källay, W. Krugluger, M. Peterlik and H. S. Cross Requires Authentication Unlicensed Licensed Download PDF	298
TGF-ßl Inhibits the Induction of Osteocalcin Gene by 1,25(OH)₂D₃ at the Level of Transcription A. Pirskanen, T. Jääskeläinen and P. H. Mäenpää Requires Authentication Unlicensed Licensed Download PDF	300
Mechanism of Action of 1,25-Dihydroxyvitamin D Differs in Kidney, Intestine, and Bone Cell Lines H. J. Armbrecht, T. L. Hodam and M. A. Boltz Requires Authentication Unlicensed Licensed Download PDF	302
mRNA Levels of the Inhibitor Protein of cAMP-Dependent Protein Kinase are Regulated by 1,25(OH)₂D₃ and Forskolin G. S. Marchetto and H. L. Henry Requires Authentication Unlicensed Licensed Download PDF	304
Vitamin D Receptor (VDR) Interactions with Vitamin D₃ Response Elements (VDRE) in the Parathyroid Hormone (PTH) and Osteocalcin Genes are Different N. S. Hawa, S. Vadher, J. L. H. O’Riordan and S. M. Farrow Requires Authentication Unlicensed Licensed Download PDF	306
Coordinate Regulation of Rat Parathyroid Gland Function by Calcium and 1,25- Dihydroxyvitamin D₃ A. J. Brown, M. Zhong, J. Finch and E. Slatopolsky Requires Authentication Unlicensed Licensed Download PDF	308
Phosphorylation Pathways Affect Binding of AP-1 and Vitamin D Receptor to their Combined Response Element in the Promoter Region of Human Osteocalcin Gene T. Jääskeläinen, A. Pirskanen and P. H. Mäenpää Requires Authentication Unlicensed Licensed Download PDF	310
Rapid Actions of Vitamin D Steroids
Transmembrane Signal Pathways Induced by Calcitriol, Estradiol, Testosterone and Progesterone in Osteoblasts M. Lieberherr, B. Grosse, M.-T. Tassin, M. Kachkache and A. Bourdeau Requires Authentication Unlicensed Licensed Download PDF	315
Non-Nuclear Actions of 1a,25(OH)₂D₃ and 24R,25(OH)₂D₃ in Mediating Intestinal Calcium Transport: The Use of Analogs to Study Membrane Receptors for Vitamin D Metabolites and to Determine Receptor Ligand Conformational Preferences A. W. Norman, M. Dormanen, W. H. Okamura, M. Hammond and I. Nemere Requires Authentication Unlicensed Licensed Download PDF	324
Nongenomic Effects of Vitamin D B. D. Boyan, V. L. Sylvia, D. D. Dean and Z. Schwartz Requires Authentication Unlicensed Licensed Download PDF	333
Binding of the Occupied Vitamin D Receptor (VDR) to Extra-Nuclear Sites: A Potential Mechanism of Nongenomic Actions of 1a,25(OH)₂D₃ Y. Kim, S. Dedhar and K. Hruska Requires Authentication Unlicensed Licensed Download PDF	341
A Common Mechanism for the Vitamin D Reeeptor Activation and for the Nongenomic Actions of Calcitriol J. Barsony, W. McKoy, I. Renyi and M. E. Liberman Requires Authentication Unlicensed Licensed Download PDF	345
The Calciotropic Hormone 1,25(OH)₂-Vitamin D₃ Stimulates Phospholipase D Activity in Cultured Muscle Cells R. Boland, S. Morelli and A. R. de Boland Requires Authentication Unlicensed Licensed Download PDF	347
Rapid Non-Genomic Effect of 1a,25-Dihydroxyvitamin D₃ on Osteoblast Nuclei A. M. Sorensen and D. T. Barati Requires Authentication Unlicensed Licensed Download PDF	349
1a,25-Dìhydroxyvitamin D₃ Induces a Rapid and Sustained Increase in Cytosolic Calcium in Cultured Human Keratinocytes D. M. Jackson and M. F. Holick Requires Authentication Unlicensed Licensed Download PDF	351
Aged-Related Changes in the Non-Genomic Response of Intestinal Mammalian Cells to 1,25-Dihydroxy-Vitamin D₃ V. Massheimer, G. Picotto, A. R. de Boland and R. Boland Requires Authentication Unlicensed Licensed Download PDF	353
Video Imaging of Intracellular Calcium in Insulinoma Cells: Effects of 1,25(OH)₂D₃ I. N. Sergeev and W. B. Rhoten Requires Authentication Unlicensed Licensed Download PDF	355
Cellular Signalling Responses Mediated by 1,25(OH)₂-Vitamin D₃ in Rat and Chick Myoblasts G. Vazquez and A. R. de Boland Requires Authentication Unlicensed Licensed Download PDF	357
Involvement of Adenylate Cyclase System in 1,25-Dihydroxyvitamin D₃ Rapid Stimulation of Ca^{2 +} Uptake by Heart Cells G. Santillân, J. Sellés and R. Boland Requires Authentication Unlicensed Licensed Download PDF	359
Specific Binding of 1,25-Dihydroxyvitamin D₃ to Rat Colonocyte Basolateral Membranes R. J. Mailloux, M. J. G. Bolt, R. K. Wali, T. A. Brasitus and M. D. Sitrin Requires Authentication Unlicensed Licensed Download PDF	361
Protein Kinase C Participates in the Signal Transduction Pathway Triggered by 1,25-Dihydroxyvitamin D₃ in Myocytes M. J. Marinissen, J. Sellés and R. Boland Requires Authentication Unlicensed Licensed Download PDF	363
Calbindins D—Function and Gene Regulation: Calcium Transport
Mechanistic Studies on Intestinal Ca^{2 +} Transport M. D. Sitrin and T. A. Brasitus Requires Authentication Unlicensed Licensed Download PDF	367
Vitamin D, the Intestinal Plasma Membrane Calcium Pump Gene Expression and the Calbindins R. H. Wasserman, J. S. Chandler, Q. Cai and R. Kumar Requires Authentication Unlicensed Licensed Download PDF	376
Tissue Specific Calbindin-D_9K Gene Regulation by Calcitriol and Sexual Hormones C. Perret, F. l’Horset, C. Blin, M. Lambert, S. Colnot and M. Thomasset Requires Authentication Unlicensed Licensed Download PDF	385
Proteins that Bind to the Calbindin-D_9K Promoter: Known Factors and a New Intestinal Factor M. Lambert, S. Colnot, C. Blin, F. l’Horset, M. Raymondjean, M. Thomasset and C. Perret Requires Authentication Unlicensed Licensed Download PDF	394
Studies of the Human Calbindin-D_9K Gene J. R. F. Walters, A. Howard, N. Moghrabi and S. Legon Requires Authentication Unlicensed Licensed Download PDF	396
Calbindins Revisited in the Rat Dental Pulp A. Berdal, A. Brehier, D. Hotton and A. Nanci Requires Authentication Unlicensed Licensed Download PDF	398
In Situ Hybridization of Calbindins mRNAs in Rat Ameloblasts D. Hotton, J. L. Davideau, J. F. Bernaudin and A. Berdal Requires Authentication Unlicensed Licensed Download PDF	400
Immunoreactive Calbindins-D_28K and _9K Mineralization of Rat Epiphyseal Chondrocytes in Culture N. Baimain, B. von Eichel, R. Toury, F. Belqasmi, M. Hauchecorne, G. Klaus, O. Mehls and E. Ritz Requires Authentication Unlicensed Licensed Download PDF	402
Regulation of Calbindin-D_28K by Parathyroid Hormone in MDBK Cells G. K. Mutema, I. N. Sergeev and W. B. Rhoten Requires Authentication Unlicensed Licensed Download PDF	404
Phosphorylation and Modulation of Calbindin D_28K by Activation of Protein Kinase C (PKC) A. M. Gagnon and J. E. Welsh Requires Authentication Unlicensed Licensed Download PDF	406
Caco-2 Cells: A Human Intestinal Cell Line for Studying the Biologic Activity of Vitamin D Analogs R. J. Wood, G. S. Reddy and J. C. Fleet Requires Authentication Unlicensed Licensed Download PDF	408
EGF Down Regulates Both Calbindin D_28K and the VDR in MDBK Cells M. Donepudi and J. E. Welsh Requires Authentication Unlicensed Licensed Download PDF	410
Does Calbindin-D_28K Buffer Intracellular Free Calcium? W. B. Rhoten and I. N. Sergeev Requires Authentication Unlicensed Licensed Download PDF	412
Calbindin-D_28K (CaBP-D_28K) in the Rat Endocrine Pancreas: In Vivo and In Vitro Immunolocalization and its Regulation by Vitamin D₃ Deficiency and 1,25- Dihydroxyvitamin D₃ P. -M. Bourlon, A. Faure-Dussert, B. Billaudel, G. Tramu, B. Sutter and M. Thomasset Requires Authentication Unlicensed Licensed Download PDF	414
Effect of Two Antiestrogens (Tamoxifen and ICI 182780) on Calbindin-D_9K Gene Expression In Vivo in the Rat Uterus, and In Vitro in Primary Cultures of Myometrial Cells C. Blin, F. l’Horset, M. Lambert, S. Colnot, T. Leclerc, M. Thomasset and C. Perret Requires Authentication Unlicensed Licensed Download PDF	416
Identification of a 9 kDa Calcium-Binding Protein in the Chick as Calbindin-D_9K S. B. Zanello, L. Drittanti, A. W. Norman and R. L. Boland Requires Authentication Unlicensed Licensed Download PDF	418
Effect of Antisense Sequences Against Calretinin on WiDr Cells J.-C. Gander, V. Gotzos, M. R. Celio and B. Schwaller Requires Authentication Unlicensed Licensed Download PDF	420
Intestinal Absorption of Calcium and Strontium Demonstrate a Similar Response to Calcitriol Treatment R. Barto, A. J. A. M. Sips, J. C. Netelenbos and W. J. F. van der Vijgh Requires Authentication Unlicensed Licensed Download PDF	422
Physiological Concentrations of 24,25(OH)₂ Vitamin D₃ Decrease the Intestinal Calcium Uptake in the Atlantic Cod, Gadus Morhua D. Larsson, B. T. Björnsson and K. Sundell Requires Authentication Unlicensed Licensed Download PDF	424
Effects of Vitamin D and DL-Buthionine-S, R-Sulfoximine on Intestinal Calcium Absorption N. Tolosa de Talamoni, V. Baudino and A. Marchionatti Requires Authentication Unlicensed Licensed Download PDF	426
1,25-(OH)₂D₃ Stimulates Ca²⁺ -Uptake Across the Duodenal Brush Border by at Least Two Independent Mechanisms R. Kaune and J. Harmeyer Requires Authentication Unlicensed Licensed Download PDF	428
Effect of Heavy Metals on the Level of Calbindin D^28K and the Assimilation of Ca in Chick Duodenum M. Valinietse, V. Bauman and D. Babarykin Requires Authentication Unlicensed Licensed Download PDF	430
Apparent Nephron Localization of the 1,25(OH)₂D₃-Stimulated Calmodulin Binding Proteins in the Rat Kidney E. K. O. Siaw, X. Qin, M. Okwueze and M. R. Walters Requires Authentication Unlicensed Licensed Download PDF	432
Raised Intestinal Calcium Secretion in the Young Oophorectomised Rat P. D. O’Loughlin and H. A. Morris Requires Authentication Unlicensed Licensed Download PDF	434
Validation of a Simple Test Measuring Intestinal Calcium Absorption Using Strontium as a Marker A. J. A. M. Sips, W. J. F. van der Vijgh and J. C. Netelenbos Requires Authentication Unlicensed Licensed Download PDF	436
Cell Differentiation
In Vitro Effects of Potent Vitamin D₃ Analogs on Proliferation and Differentiation of Seven Human Breast Cancer Cell Lines E. Elstner, S. de Vos, S. Pakkala, D. Heber, L. Binderup, M. Uskokovic, T. Umiel and H. P. Koeffler Requires Authentication Unlicensed Licensed Download PDF	441
Terminal Differentiation of Human Leukemia Cells (HL60) by a Combination of 1,25-Dihydroxyvitamin D₃ and Retinoic Acid (All Trans or 9-Cis) A. Verstuyf, C. Mathieu, L. Verlinden, B. T. Keng and R. Bouillon Requires Authentication Unlicensed Licensed Download PDF	449
1,25-Dihydroxyvitamin D₃ Induces Growth of Thyroid C Cells and Inhibits Calcitonin Secretion In Vitro M. Lazaretti-Castro, J. G. H. Vieira and F. Raue Requires Authentication Unlicensed Licensed Download PDF	451
Differentiation of Human Myelomonocytic Leukemia Cell Lines by Retinoic Acid and Vitamin D₃ Analogs, MC903 and EB1089: Characterization of Cooperative Effects T. Commes, H. Defacque, C. Sevilla, F. Yajid, J. Dornand and J. Marti Requires Authentication Unlicensed Licensed Download PDF	453
Effect of Ascorbate and Calcitriol on HL-60 Promyelocytic Cell Line Proliferation and Differentiation G. Löpez-Lluch, M. I. Burön, F. J. Alcai’n, F. Borrego, J. M. Quesada and P. Navas Requires Authentication Unlicensed Licensed Download PDF	455
Evidence for a Vitamin D Paracrine System Regulating Fetal Pneumocyte Type II Maturation: Local Synthesis of 1,25-(OH)₂D₃ by Lung Fibroblasts T. M. Nguyen, S. Koite, H. Guillozo, L. Marin, C. Tordet and M. Garabedian Requires Authentication Unlicensed Licensed Download PDF	457
Inhibition of IEC-6 Cell Growth by 1,25(OH)₂D₃: Involvement of TGFß D. Bonell and J. Welsh Requires Authentication Unlicensed Licensed Download PDF	459
Interactions between Vitamin D Derivatives, Retinoids and Granulocyte Macrophage - Colony Stimulating Factor in Leukemic Cell Differentiation S. Y. James, S. M. Kelsey, M. A. Williams, A. C. Newlands and K. W. Colston Requires Authentication Unlicensed Licensed Download PDF	461
1,25(OH)₂D₃ and Agents that Increase Intracellular cAMP Synergistically Inhibit the Proliferation of Mouse Fibroblasts N. Saati, A. Ravid, U. A. Liberman and R. Koren Requires Authentication Unlicensed Licensed Download PDF	463
1a,25-Dihydroxyvitamin D Rapidly Triggers Inhibition of Fibroblast Contraction of Collagen Lattices D. Greiling and R. Thieroff-Ekerdt Requires Authentication Unlicensed Licensed Download PDF	465
Cancer Requires Authentication Unlicensed Licensed Download PDF	467
Immunology Requires Authentication Unlicensed Licensed Download PDF	529
Dermatology Requires Authentication Unlicensed Licensed Download PDF	559
Neurosciences Requires Authentication Unlicensed Licensed Download PDF	619
Renal Osteodystrophy Requires Authentication Unlicensed Licensed Download PDF	647
Bone and Cartilage Requires Authentication Unlicensed Licensed Download PDF	673
Miscellaneous Biological Actions of Vitamin D Metabolites and Analogs Requires Authentication Unlicensed Licensed Download PDF	735
Assays for Vitamin D Steroids Requires Authentication Unlicensed Licensed Download PDF	747
Nutrition Requires Authentication Unlicensed Licensed Download PDF	767
Osteoporosis Requires Authentication Unlicensed Licensed Download PDF	797
Neonatology and Pregnancy Requires Authentication Unlicensed Licensed Download PDF	867
Gerontology Requires Authentication Unlicensed Licensed Download PDF	875
Other Basic Science Topics Requires Authentication Unlicensed Licensed Download PDF	883
Other Clinical Topics Requires Authentication Unlicensed Licensed Download PDF	897
Author Index Requires Authentication Unlicensed Licensed Download PDF	937
Subject Index Requires Authentication Unlicensed Licensed Download PDF	947
Cell Line Index Requires Authentication Unlicensed Licensed Download PDF	965
Zoo Index Requires Authentication Unlicensed Licensed Download PDF	967
Backmatter Requires Authentication Unlicensed Licensed Download PDF	968

Language: English
Publisher: De Gruyter
Edition: Reprint 2020
Pages
- Front matter: 36
- Main content: 966
Illustrations
- Illustrations: 377
- Tables: 124
Keywords: Vitamin-D-Gruppe

eBook

Published: October 12, 2020
ISBN: 9783110882513

Hardcover

Published: November 1, 1994
ISBN: 9783110141573