7 St. Andrews, Scotland, September 21–24, 1982

Published by De Gruyter 1983

7 St. Andrews, Scotland, September 21–24, 1982

Edited by: John A. Blair

Part of the multi-volume work Chemistry and Biology of Pteridines

https://doi.org/10.1515/9783111619453

Contents

Frontmatter Publicly Available Download PDF	I
Preface Requires Authentication Unlicensed Licensed Download PDF	V
ACKNOWLEDGEMENTS Requires Authentication Unlicensed Licensed Download PDF	VII
PARTICIPANTS Requires Authentication Unlicensed Licensed Download PDF	IX
Contents Publicly Available Download PDF	XIII
The Gowland Hopkins Lecture: Transport of Folate and Pterin Compounds F.M. Huennekens, M.R. Suresh, C.E. Grimshaw, D.W. Jacobsen, E.T. Quadros, Κ.S. Vitols and G.B. Henderson Requires Authentication Unlicensed Licensed Download PDF	1
Chemical Aspects (1)
Scottish International Education Trust Lecture: Synthetic Methods in Pteridine Chemistry: Some Applications to Pteridine Natural Products Edward C. Taylor Requires Authentication Unlicensed Licensed Download PDF	23
Synthesis, Chemical and Enzymatic Properties, and Therapeutic Potential of 6,6-Disubstituted Tetrahydroand Quinoid-Dihydro-Pterins Steven W. Bailey and June E. Ayling Requires Authentication Unlicensed Licensed Download PDF	51
The Structure of Quinonoid Dihydropterins [2-Amino-7,8(6H)-Dihydropteridin-4-ones] Wilfred L.F. Armarego and Paul Waring Requires Authentication Unlicensed Licensed Download PDF	57
Some Simple s-Triazolopteridines Desmond J. Brown and Kazuo Shinozuka Requires Authentication Unlicensed Licensed Download PDF	63
Linear Tricyclic Analogs of Pteridines William Pendergast and Joseph H. Chan Requires Authentication Unlicensed Licensed Download PDF	69
Reactions of Furazano [3,4-djPyrimidines and their Application to Pteridine Synthesis Peter Boyle and Ronan Lockhart Requires Authentication Unlicensed Licensed Download PDF	73
Syntheses of some Blocked 7,8-Dihydropteridines Bobert C. Cameron, William J.S. Lyall, Sidney H. Nicholson, David H. Bobinson, Colin J. Suckling and Hamish C.S. Wood Requires Authentication Unlicensed Licensed Download PDF	79
Synthesis of Chiral Reduced Pteridine Coenzymes Paul M. Doyle, Akos Szakolcai and Douglas W. Young Requires Authentication Unlicensed Licensed Download PDF	85
Report on Discussions S. J. Benkovic Requires Authentication Unlicensed Licensed Download PDF	91
Chemical Aspects (2)
Reactivity of Pteridines Wolfgang Pfleiderer, Ralph Baur, Michael Bartke and Hermann Lut Requires Authentication Unlicensed Licensed Download PDF	93
Synthesis and Antitumor Activity of 10-Deazaminopterins J. I. DeGraw, V. H. Brown, H. Tagawa, R. L. Kisliuk, Y. Gaumont and F. M. Sirotnak Requires Authentication Unlicensed Licensed Download PDF	109
Synthesis and Biological Activity of 5-Deazafolic Acid and 5-Deazaaminopterin Edward C. Taylor, Chi-Ping Tseng, Peter J. Harrington, G. Peter Beardsley, Andrew Rosowsky and Michael Wick Requires Authentication Unlicensed Licensed Download PDF	115
The Nor-Analogues of Folic Acid M.G. Nair, Mary K. Rozmyslovicz, R.L. Kisliuk, Y. Gaumont and F.M. Sirotnak Requires Authentication Unlicensed Licensed Download PDF	121
Report on Discussions B. Roth Requires Authentication Unlicensed Licensed Download PDF	127
Neurochemical and Clinical Aspects
Metabolism of Pteridine Cofactors in Neurochemistry Charles A. Nichol, O. Humberto Viveros, David S. Duch, Martha M. Abou-Donia and Gary K. Smith Requires Authentication Unlicensed Licensed Download PDF	131
Pteridines in Cancer and Other Diseases Katharina Rokos, Hartmut Rokos, Hildegard Frisius and Michael Hüfner Requires Authentication Unlicensed Licensed Download PDF	153
Dihydropteridine Reductase Activity in Human Breast Cancer. Studies of 580 Cases and Correlations with Hormone Receptors and Cellular Typing Jean-Louis Dhondt, Christophe Herlin, Jacques Bonneterre, M. Claude Vie, Jean Lefebvre and Alain Demaille Requires Authentication Unlicensed Licensed Download PDF	159
A Critical Appraisal of Methods for the Quantitative Analysis of Tetrahydrobiopterin, Dihydrobiopterin and Biopterin in Human Urine, Serum and CSE J.A. Blair, S.B. Whitburn, Α.E. Pheasant, R.J. Leeming, C. Morar and A. Al-Beir Requires Authentication Unlicensed Licensed Download PDF	165
Inhibition of Pterin Biosynthesis in the Adrenergic Neuroblastoma N1E115 by Tetrahydrobiopterin and Folate Gregory Kapatos and Seymour Kaufman Requires Authentication Unlicensed Licensed Download PDF	171
Penetration of Reduced Pterins into Rat Brain: Effect on Biogenic Amine Synthesis Robert A. Levine, Walter Lovenberg, A. Niederwieser, W. Leimbacher, U. Redweik, W. Staudenmann and H.-Ch. Curtius Requires Authentication Unlicensed Licensed Download PDF	177
Neopterin Deficiency (GTP Cyclohydrolase I Deficiency), a New Variant of Hyperphenylalaninemia A. Niederwieser, W. Staudenmann, M. Wang, H.-Ch. Curtius, M. Atarés and J. Cardesa-Garcia Requires Authentication Unlicensed Licensed Download PDF	183
Folate Pathways in Cells from Fragile X Syndrome Patients and Carriers Richard W. Erbe and Jin-Chen C. Wang Requires Authentication Unlicensed Licensed Download PDF	189
Report on Discussions R. G. H. Cotton Requires Authentication Unlicensed Licensed Download PDF	195
Enzymology
The Interaction of Substrates and Inhibitors with Dihydrofolate Reductase Gordon C.K. Roberts Requires Authentication Unlicensed Licensed Download PDF	197
Catalytic Site of Dihydrofolate Reductase Raymond L. Blakley, Lennie Cocco, John A. Montgomery, Carroll Temple, Barbara Roth, Susan Daluge and Robert E. London Requires Authentication Unlicensed Licensed Download PDF	215
Structure, Function and Affinity Labelling Studies of Dihydrofolate Reductase J.H. Freisheim, S. S. Susten, T. J. Delcamp, A. Rosowsky, J. E. Wright, R. J. Kempton, D. T. Blankenship, P. L. Smith and A .A. Kumar Requires Authentication Unlicensed Licensed Download PDF	223
Methylene Tetrahydrofoíate Reductase: Studies in a Human Mutant and Mammalian Liver Garry P. Lewis and Peter B. Rowe Requires Authentication Unlicensed Licensed Download PDF	229
Studies on Methylenetetrahydrofolate Reductase from Pig Liver: Catalytic Mechanism and Regulation by Adenosylmethionine Maria A. Vanoni, S. Colette Daubner, David P. Ballou and Rowena G. Matthews Requires Authentication Unlicensed Licensed Download PDF	235
Role of Methylenetetrahydrofolic Acid Reductase in Regulation of Folic Acid Metabolism and its Relation to the Methyl Trap Hypothesis E.L.R. Stokstad, M.M-S. Chan and J.E. Watson Requires Authentication Unlicensed Licensed Download PDF	241
The Mechanism of Action of the Transformylase Enzymes Gary K. Smith, W. Thomas Mueller, Patricia A. Benkovic, Lawrence J. Slieker, Charles W. DeBrosse and Stephen J. Benkovic Requires Authentication Unlicensed Licensed Download PDF	247
Folypolyglutamate Synthesis in Neurospora Crassa E.A. Cossins and P. Y. Chan Requires Authentication Unlicensed Licensed Download PDF	251
Report on Discussions D. P. Baccanari and L. F. Kuyper Requires Authentication Unlicensed Licensed Download PDF	257
Clinical Aspects: Cancer
Folates and Cancer Chemotherapy J.R. Bertino and J. J. McGuire Requires Authentication Unlicensed Licensed Download PDF	263
Inability to Increase the Mobilisation of Liver Folates During Folate Deficiency Suggesting that this and Other Organs do not act as a Potential Folate Store for Marrow and Other Rapidly Proliferating Cells J. M. Scott, A. Molloy, A. Smithwick, P. McGing and D. G. Weir Requires Authentication Unlicensed Licensed Download PDF	275
A High Molecular Weight Nonfunctional Immunoreactive Form of Dihydrofolate Reductase in L1210 Leukaemia Cells Sheldon Rothenberg and M. Perwaiz Iqbal Requires Authentication Unlicensed Licensed Download PDF	281
Further Characterization of the Pterdine Binding Variant of Alphas-Acid Glycoprotein, Accumulated in the Blood of Patients with Malignant Diseases Irmgard Ζieger, Wilfred L. F. Armarego and Michael Fink Requires Authentication Unlicensed Licensed Download PDF	287
Structure-Activity Relationships among 5-Substituted Lipophilic Diaminopyrimidine Antineoplastic Antifolates Vivian Cody, Elaine DeJarnette and Sigmund F. Zakrzewski Requires Authentication Unlicensed Licensed Download PDF	293
Attempts to Design Inhibitors of Dihydrofolate Reductase Using Interactive Computer Graphics with Real Time Energy Calculations E. A. Potterton, A. J. Geddes and A. C. T. North Requires Authentication Unlicensed Licensed Download PDF	299
Control of Methotrexate Polyglutamate Synthesis in Cultured Rat Hepatoma Cells John Galivan and Malgorzata Balinska Requires Authentication Unlicensed Licensed Download PDF	305
Differential Effects of Methotrexate or Fluorodeoxyuridine upon Mitochondrial and Cellular Nucleotide Pools Richard K. Bestwick, Ginnie L. Moffett, Craig Spiro and Christopher K. Mathews Requires Authentication Unlicensed Licensed Download PDF	311
Report on Discussions J. M. Whiteley Requires Authentication Unlicensed Licensed Download PDF	317
Bioorganic Chemistry and Enzymology
Chemical Mechanisms in the Action of Pteridine Coenzymes Douglas W. Young Requires Authentication Unlicensed Licensed Download PDF	321
Irreversible Inactivation of Rat Liver Phenylalanine Hydroxylase by Reaction with (6S)-L-Erythro-Tetrahydrobiopterin Michael Parniak and Seymour Kaufman Requires Authentication Unlicensed Licensed Download PDF	345
p-Azidophenylalanine: A Potential Photoaffinity Probe for Rat-Liver Phenylalanine Hydroxylase Stephanie Webber and John M. Whiteley Requires Authentication Unlicensed Licensed Download PDF	351
Pyrimidine Models for the Cofactor of Phenylalanine Hydroxylase Autoxidation of 2,4,5,-Triamino-6-Hydroxypyrimidines J. A. Jongejan, H. I. X. Mager and W. Berends Requires Authentication Unlicensed Licensed Download PDF	357
Activation of Molecular Oxygen by Tetrahydropterin Monooxygenases June E. Ayling and Steven W. Bailey Requires Authentication Unlicensed Licensed Download PDF	363
Mechanistic Studies on Phenylalanine Hydroxylase: Structural Determination of the Tetrahydropterin Intermediates Robert A. Lazarus, Charles W. DeBrosse and Stephen J. Benkovic Requires Authentication Unlicensed Licensed Download PDF	369
Properties of Thymidylate Synthase from Streptococcus Faecium R. L. Kisliuk, Κ. N. Rao, Y. Gaumont, R. Deschenes, K. Vestal, M. Karasik, G. F. Maley, M. G. Nair and C. M. Baugh Requires Authentication Unlicensed Licensed Download PDF	375
Cloning the Gene for Eukaryotic C1-THF Synthase Chuck Stäben and Jesse C. Rabinowitz Requires Authentication Unlicensed Licensed Download PDF	381
Report on Discussions W. L. F. Armarego Requires Authentication Unlicensed Licensed Download PDF	387
Biochemistry and Biology
The Enzymatic Synthesis of the Drosopterins: Identification of a Pyrimidodiazepine as an Intermediate Gregory J. Wiederrecht, Duncan R. Paton and Gene M. Brown Requires Authentication Unlicensed Licensed Download PDF	391
The Common Precursor of Sepiapterin and Drosopterin in Drosophila: Enzymatic and Chemical Synthesis W. G. Hearl, D. Dorsett and K. Bruce Jacobson Requires Authentication Unlicensed Licensed Download PDF	397
The Common Precursor of Sepiapterin and Drosopterin in Drosophila: Enzymatic and Chemical Synthesis H. Wächter, D. Fuchs, Α. Hausen and G. Reibnegger Requires Authentication Unlicensed Licensed Download PDF	403
The Role of Pteridines in Regulation of Growth Nancy Klein Amy and Jeffrey B. Miller Requires Authentication Unlicensed Licensed Download PDF	409
Evidence for a Folate Bound to Rat Hepatic Uroporphyrinogen III Cosynthase and its Role in the Biosynthesis of Heme W. N. Piper, J. Tse, R. P. Clement and M. Kohashi Requires Authentication Unlicensed Licensed Download PDF	415
Report on Discussions P. H. Boyle Requires Authentication Unlicensed Licensed Download PDF	421
Presented Papers
Aerobic Oxidation of 5,6,7,8-Tetrahydroneopterin Wilfred L. F. Armarego and David Randies Requires Authentication Unlicensed Licensed Download PDF	423
The Conformations of 7,8 (6H)-Dihydropterin Substrates and the Activity of Dihydropteridine Reductase (E.C.1.6.99.10) Wilfred L. F. Armarego and Paul Waring Requires Authentication Unlicensed Licensed Download PDF	429
Dihydrofolate Reductase: The Stereochemistry of Inhibitor Selectivity D. A. Matthews, J. T. Bolin, D. J. Filman, Κ. W. Volz and J. Kraut Requires Authentication Unlicensed Licensed Download PDF	435
Synthesis of an 8-Deaza Analog of the Intermediate in the Thymidylate Synthetase Reaction (1) Arthur D. Broom and Ananthachari Srinivasan Requires Authentication Unlicensed Licensed Download PDF	445
The Synthesis of Analogs of Pteroylglatamyl-y-Phosphate as Potential Inhibitors of Folylpolyglutamate Synthetase Kuo-Chang Tang and James K. Coward Requires Authentication Unlicensed Licensed Download PDF	451
Synthesis and Activity of 8,10-Dideazaminopterin J. I. DeGraw, L. F. Kelly, R. L. Kisliuk, Y. Gaumont and F. M. Sirotnak Requires Authentication Unlicensed Licensed Download PDF	457
CNDO/2 Molecular Orbital Calculations on the Antifolate DAMP and Some of its Analogues: Conformational Characteristics William J. Welsh, James E. Mark, Vivian Cody and Sigmund F. Zakrzewski Requires Authentication Unlicensed Licensed Download PDF	463
Fluorescent Analogues of Methotrexate as Probes for Folate Antagonist Molecular Receptors J. H. Freisheim, A. A. Kumar, A. M. Black, G. M. Anstead, R. J. Kempton and S. S. Susten Requires Authentication Unlicensed Licensed Download PDF	469
Dihydrofolate Reductase Overproduction Identified by Flow Cytometry Using a Fluorescent Methotrexate Analogue Andre Rosowsky, Joel E. Wright, G. Peter Beardsley and Howard M. Shapiro Requires Authentication Unlicensed Licensed Download PDF	475
New Syntheses and Transformations of Some Pteridines and Pteridine 3-Oxides Marijan Kočevar, Branko Stanovnik and Miha Tišler Requires Authentication Unlicensed Licensed Download PDF	481
Photooxidation of Mercaptopteridines Armin Heckel and Wolfgang Pfleiderer Requires Authentication Unlicensed Licensed Download PDF	487
Reactivity of 6,7-Dichloro-1, 3-Dimethyllumazine Khaled Abou-Hadeed and Wolfgang Pfleiderer Requires Authentication Unlicensed Licensed Download PDF	493
Synthesis, Reactivity and Properties of 8-Substituted 2-Thio- and 2,4-Dithiolumazines Walter Hübsch and Wolfgang Pfleiderer Requires Authentication Unlicensed Licensed Download PDF	499
The Activity of Sulfonamide-Substituted Benzylpyrimidines Against Dihydropteroate Synthase, Dihydrofolate Reductase, and Bacterial Cell Cultures Richard M. Hyde, Richard A. Paterson, Christopher R. Beddell, John N. Champness, David K. Stammers, Dorothea J. Baker, Peter J. Goodford, Lee F. Kuyper, Robert Ferone, Barbara Roth and Lynn P. Elwell Requires Authentication Unlicensed Licensed Download PDF	505
Structural Studies of Antifolate Drugs Carl H. Schwalbe and Vivian Cody Requires Authentication Unlicensed Licensed Download PDF	511
Isolation and Characterization of a Novel Folate Antagonist Gerhard Schlingraann and E. L. Robert Stokstad Requires Authentication Unlicensed Licensed Download PDF	517
Synthesis and Biological Properties of the S-8 Analog of 7,8-Dihydropteridinealcohol K. Visser and J. K. Seydel Requires Authentication Unlicensed Licensed Download PDF	523
Synthesis of Dihydrobiopterin from Dihydroneopterin Triphosphate in Rat Tissues and Human Blood Corpuscles: Diagnosis of Atypical Phenylketonuria due to Biopterin Deficiency by Assay of an Enzyme Involved in the Synthesis Miki Akino, Shin'ichi Yoshioka, Masahiro Masada, Kayo Inoue, Takeo Yoshida, Takashi Mizokami and Nobutake Matsuo Requires Authentication Unlicensed Licensed Download PDF	529
Stereospecific Enzyme Mediated Syntheses of Tetrahydrofolate Derivatives Lilias Bees, Colin J. Suckling, Edward Talente and Hamish C. S. Wood Requires Authentication Unlicensed Licensed Download PDF	533
Immobilization of Dihydrofolate Reductase from Amethopterin Resistant Lactobacillus Casei Faizy Ahmed and R. Bruce Dunlap Requires Authentication Unlicensed Licensed Download PDF	539
X-Ray Studies of the Binding of Trimethoprim, Methotrexate, Pyrimethamine and Two Trimethoprim Analogues to Bacterial Dihydrofolate Reductase D. J. Baker, C. R. Beddell, J. N. Champness, P. J. Goodford, F. E. Norrington, B. Roth and D. K. Stammers Requires Authentication Unlicensed Licensed Download PDF	545
A New Spectrophotometry Method for the Assessment of Tight Binding Benzyldiaminopyrimidine Inhibitors of Dihydrofolate Reductase J. G. Dann Requires Authentication Unlicensed Licensed Download PDF	551
Two Interconverting Conformers of a Drug-Receptor Complex: The Lactobacillus Casei Dihydrofolate Reductase-NADP⁺ - Trimethoprim Complex A. W. Bevan, B. Birdsall, G. C. K. Roberts, J. Feeney, A. Gronenborn, G. M. Clore and A. S. V. Burgen Requires Authentication Unlicensed Licensed Download PDF	557
Multiple Conformations of the Dihydrofolate Reductase- Folate-NADP⁺ Complex B. Birdsall, A. Gronenborn, G. M. Clore, E. I. Hyde, G. C. K. Roberts, J. Feeney and A. S. V. Burge Requires Authentication Unlicensed Licensed Download PDF	563
The Three-Dimensional Structure of Mouse L1210 Dihydrofolate Reductase D. K. Stammers, J. Ν. Champness, J. G. Dann and C. R. Beddell Requires Authentication Unlicensed Licensed Download PDF	567
Isolation and Amino Acid Sequence Studies of Dihydrofolate Reductase from Neisseria Gonorrhoeae D. Stone, S. J. Paterson, R. Tansik and D. P. Baccanari Requires Authentication Unlicensed Licensed Download PDF	573
Purification of 7,8-Dihydropteroate-Synthetase from E. Coli by Affinity- and Hydrophobic Interaction Chromatography Rainer Bartels and Lothar Bock Requires Authentication Unlicensed Licensed Download PDF	579
Isolation and Characterization of an E. Coli Mutant Affected in Dihydrofolate- and Folylpolyglutamate- Synthetase R. Ferone, S. C. Singer, M. H. Hanlon and S. Roland Requires Authentication Unlicensed Licensed Download PDF	585
Purification and Properties of 5-Formyltetrahydrofolate Cyclodehydrase from Rabbit Liver LaVerne Schirch and Sam Hopkins Requires Authentication Unlicensed Licensed Download PDF	591
Structural Studies on Formyl-Methenyl-Methylene Tetrahydrofolate Synthetase from Rabbit Liver Darrell Peterson and LaVerne Schirch Requires Authentication Unlicensed Licensed Download PDF	597
Utilization of Folate Polyglutamate for Growth by Lactobacillus Casei Mary-Frances Maclntyre, Bernard A. Cooper and Helena Lue-Shing Requires Authentication Unlicensed Licensed Download PDF	603
Folate and Folate Enzymes as Structural Components of Bacteriophage Particles L. M. Kozloff, D. Sadewasser and M. Lute Requires Authentication Unlicensed Licensed Download PDF	609
Studies on the Substrate Specificity of Mammalian Folylpolyglutamate Synthetase J. J. McGuire, P. Hsieh, J. R. Bertino and J. Κ. Coward Requires Authentication Unlicensed Licensed Download PDF	615
Properties of Corynebacterium Species Dihydrofolate Synthetase-Folylpolyglutamate Synthetase Barry Shane Requires Authentication Unlicensed Licensed Download PDF	621
Purification and Characterization of Folylpolyglutamate Synthetase from Lactobacillus Casei and Hog Liver Andrew L. Bognar, David J. Cichowiez and Barry Shane Requires Authentication Unlicensed Licensed Download PDF	627
The Molybdenum Cofactor from Xanthine Oxidase: Quantitative Assay of the Molybdenum Cofactor by Activation of Nitrate Reductase Activity in Extracts of the Nit-1 Mutant of Neurospora crassa Timothy R. Hawkes and Robert C. Bray Requires Authentication Unlicensed Licensed Download PDF	633
Structural Studies of Calf Thymus Thymidylate Synthase Chandra M. Dwivedi, Roy L. Kisliuk and Gladys F. Maley Requires Authentication Unlicensed Licensed Download PDF	639
A Comparison of the T-Even Phage Induced and Escherichia Coli Thymidylate Synthases Gladys F. Maley, Marlene Beifort and Frank Maley Requires Authentication Unlicensed Licensed Download PDF	645
Thermophilicity of Dihydrofolate Reductase and Thymidylate Synthetase from a Thermophilic Microorganism Frederika Mandelbaum-Shavit, Jonathan Reizer and Nathan Grossowicz Requires Authentication Unlicensed Licensed Download PDF	651
Chemical Characterization of Two Folate-Binding Proteins from Mitochondria: Dimethylglycine Dehydrogenase and Sarcosine Dehydrogenase Robert J. Cook and Conrad Wagner Requires Authentication Unlicensed Licensed Download PDF	657
Allosteric Mung Bean (Vigna radiata) Serine Hydroxylmethyl-Transferase D. Narasimha Rao and N. Appaji Rao Requires Authentication Unlicensed Licensed Download PDF	663
Comparative Study of the Eye Colour Mutants of Drosophila Melanogaster: Quantification of the Eye-Pigments and Related Metabolites Juan Ferré, Francisco Silva, Maria Dolores Real and José Luis Ménsua Requires Authentication Unlicensed Licensed Download PDF	669
Studies on Sepialumazine, the Characteristic Larval Integument Pigment of the Bombyx Mori Kiuki Mutant Motoo Tsusue, Toshio Mazda and Sakae Sakate Requires Authentication Unlicensed Licensed Download PDF	675
Macromolecular Regulation of Sepiapterin and Drosopterin Synthesis in the Purple Mutant of Drosophila K. Bruce Jacobson, John J. Yim and C. R. Wobbe Requires Authentication Unlicensed Licensed Download PDF	681
The Hydroxylation of Phenylpropanoids by Euglena gracilis : Role of Pteridines Rita Fink, Eva Paur and Elstner Requires Authentication Unlicensed Licensed Download PDF	687
Studies with Old Yellow Enzyme, Reconstitution with Lumazine Analogs as Coenzyme GUnter Wetzel and Sandro Ghisla Requires Authentication Unlicensed Licensed Download PDF	693
Biosynthesis of Riboflavin Origin of the Xylene Ring Adelbert Bacher, Quang Le Van, Matthias Bühler, Paul J. Keller and Heinz G. Floss Requires Authentication Unlicensed Licensed Download PDF	699
Biosynthesis of Riboflavin Synthesis of the Substrate and of Substrate Analogiies for Pyrimidine Deaminase Peter Nielsen and Adelbert Bacher Requires Authentication Unlicensed Licensed Download PDF	705
Metabolism and Function of Pterin Compounds in Seed Germination Masahiro Kohashi, Kazuhiro Tornita and Kazuo Iwai Requires Authentication Unlicensed Licensed Download PDF	711
Thymidylate Synthetase During Proliferation and Differentiation of Physarum polycephalum Peter Gröbner and Peter Loidl Requires Authentication Unlicensed Licensed Download PDF	717
Influence of Vitamin B₁₂ on Folate Metabolism in Lactobacillus Leichmannii C. P. P. Nair and J. M. Noronha Requires Authentication Unlicensed Licensed Download PDF	723
High-Affinity Binding of Folate to a Small and Large Molecular Size Protein from Human Milk Steen Ingemann Hansen, Jan Holm and Jǿrgen Lyngbye Requires Authentication Unlicensed Licensed Download PDF	729
High-Affinity Folate Binding in Leukocytes from Normal Subjects Displays Positive Cooperativity, and the Affinity Depends on the Protein Concentration Jan Holm, Steen Ingemann Hansen and Jǿrgen Lyngbye Requires Authentication Unlicensed Licensed Download PDF	735
Characteristics of 5-Methyltetrahydrofolate Binding to the Folate-Binding Protein from Cow's Whey Jǿrgen Lyngbye, Steen Ingemann Hansen and Jan Holm Requires Authentication Unlicensed Licensed Download PDF	741
Interactions of Folate-Dependent Enzymes of DNA Precursor Metabolism in T4 Phage-Infected Bacteria J. R. Allen, Joseph W. Booth, Daniel A. Goldman, Gerald W. Lasser, Sarla Purohit, R. Geoffrey Sargent and Christopher K. Mathews Requires Authentication Unlicensed Licensed Download PDF	747
The Regulation of Biopterin Biosynthesis in the Rat S. Milstien and S. Kaufman Requires Authentication Unlicensed Licensed Download PDF	753
Biosynthesis of Tetrahydrobiopterin in Mammalian Tissues by De Novo and Salvage Pathways Charles A. Nichol, Gary K. Smith and David S. Duch Requires Authentication Unlicensed Licensed Download PDF	759
Perspectives on Tetrahydrobiopterin Biosynthesis in Mammals H.-Ch. Curtius, M. Häusermann, D. Heintel, A. Niederwieser and Robert A. Levine Requires Authentication Unlicensed Licensed Download PDF	765
Human Dihydropteridine Reductase (DHPR) Deficiency Frank A. Firgaira, Richard G.H. Cotton and David M. Danks Requires Authentication Unlicensed Licensed Download PDF	771
Coordinate Regulation of Guanosine Triphosphate Cyclohydrolase and Tetrahydrobiopterin in Adrenal Medullary Chromaffin Cells M. M. Abou-Donia, A. J. Daniels, S. P. Wilson, C. A. Nichol and O. H. Viveros Requires Authentication Unlicensed Licensed Download PDF	777
Regulation of Adrenocortical Guanosine Triphosphate Cyclohydrolase and Tetrahydrobiopterin in Normal and Spontaneously Hypertensive Rats Martha M. Abou-Donia, Alejandro J. Daniels, Charles A. Nichol and O. Humberto Viveros Requires Authentication Unlicensed Licensed Download PDF	783
Inhibition of Brain Sepiapterin Reductase by a Catecholamine and an Indoleamine S. Katoh, T. Sueoka and S. Yamada Requires Authentication Unlicensed Licensed Download PDF	789
Mouse Mastocytoma Tryptophan Hydroxylase: Role of Iron and Catalase in the Expression of Enzyme Activity after Activation by Anaerobic Preincubation with Dithiothreitol Hiroyuki Hasegawa, Mariko Yanagisawa, Fumio Inoue and Arata Ichiyama Requires Authentication Unlicensed Licensed Download PDF	795
Folic Acid Induced Kindling in Rats: Changes in Brain Amino Acids R.A. O'Donnell, M.J. Leach and A. A. Miller Requires Authentication Unlicensed Licensed Download PDF	801
Impaired Pteroylpolyglutamate Synthesis in the Cobalamin-Inactivated Rat Janet Perry, I. Chanarin, Rosemary Deacon and M. Lumb Requires Authentication Unlicensed Licensed Download PDF	807
A Radioimmunoassay for Determination of D-Erythro- Neopterin Hartmut Rokos and Katharina Rokos Requires Authentication Unlicensed Licensed Download PDF	815
Radioimmunoassay for Neopterin in Body Fluid and Tissues Toshiharu Nagatsu, Makoto Sawada, Tokio Yamaguchi, Takashi Sugimoto, Sadao Matsuura, Miki Akino, Nobuhiko Nakazawa and Hiroshi Ogawa Requires Authentication Unlicensed Licensed Download PDF	821
A Specific Antiserum Against Tetrahydrobiopterin: Its Preparation and Application to Immunohistochemistry Sadao Matsuura, Takashi Sugimoto, Ikuko Nagatsu, Tokio Yamaguchi and Toshiharu Nagatsu Requires Authentication Unlicensed Licensed Download PDF	827
Speculation on the Mechanism of Therapeutic Action of Tetrahydrobiopterin in Human Disease Robert A. Levine, Walter Lovenberg, H.-Ch. Curtius and A. Niederwieser Requires Authentication Unlicensed Licensed Download PDF	833
Correlation of Tetrahydrobiopterin Content and Guanosine Triphosphate Cyclohydrolase Activity in Cells and Tissues David S. Duch and Charles A. Nichol Requires Authentication Unlicensed Licensed Download PDF	839
Unconjugated Pteridines in Human Physiological Fluids. Normal and Pathological Profiles J.-L. Dhondt, Z. Bellahsene, C. Largilliere, J. Bonneterre, P. Vanhille, C. Noel, P. Choteau and J. P. Farriaux Requires Authentication Unlicensed Licensed Download PDF	845
Biopterin and Phenylalanine Metabolism During Early Liver Regeneration Jean-Louis Dhondt, Gregory Kapatos, Michael Parniak, Harvey Wilgus and Seymour Kaufman Requires Authentication Unlicensed Licensed Download PDF	851
GTP-Cyclohydrolase Activities in Rat Liver Jean-Louis Dhondt, Zina Bellahsene, Jean-Pierre Farriaux and Michel Dautrevaux Requires Authentication Unlicensed Licensed Download PDF	857
Phenylalanine Hydroxylase Assay Using Biopterin and Synthetic Pteridine Helen K. Berry and Monica Hsieh Requires Authentication Unlicensed Licensed Download PDF	863
Dihydropteridine Reductase Levels in Human Normal and Neoplastic Tissues C. Eggar, P.A. Barford, J. A. Blair, A. E. Pheasant, A. E. Guest and G. D. Oates Requires Authentication Unlicensed Licensed Download PDF	869
Investigations of Tissue Folates in Normal and Malignant Tissues A. E. Pheasant, J. Bates, J. A. Blair and R. Nayyir-Mazhir Requires Authentication Unlicensed Licensed Download PDF	875
Blood Cell Biopterin as an Indicator of Transplanation- Induced Hemopoiesis and Leukemic Cell Proliferation Michael Fink, Irmgard Ziegler, Hans-Jochen Kölb, Ulrich Bodenberger and Wolfgang Wilmanns Requires Authentication Unlicensed Licensed Download PDF	879
Assessment of Urinary Neopterin in the Early Diagnosis of Human Allograft Rejection D. Fuchs, Α. Hausen, G. Reibnegger, H. Wächter, Ch. Huber, R. Margreiter and M. Spielberger Requires Authentication Unlicensed Licensed Download PDF	885
Behaviour of Neopterin Levels in Patients with Haematological and Gynaecological Neoplasms G. Reibnegger, D. Fuchs, A. Hausen and H. Wächter Requires Authentication Unlicensed Licensed Download PDF	891
Pteridines in Dictyostelium discoideum and Physarum polycephalum Peter Loidl, Dietmar Fuchs, Peter Gröbner, Arno Hausen, Gilbert Reibnegger, Helmut Wächter, Manfred Schweiger and Günther Gerisch Requires Authentication Unlicensed Licensed Download PDF	897
Biochemical and Chemotherapy Studies on BW 301U, a Novel Lipophilic 2,4-Diaminopyridopyrimidine Antifolate David S. Duch and Charles A. Nichol Requires Authentication Unlicensed Licensed Download PDF	903
Toxicity of a Series of Antifolate Compounds in a Methotrexate-Resistant Celi Line Michael R. Hamrell Requires Authentication Unlicensed Licensed Download PDF	909
Interaction of Methotrexate Poly(L-Lysine) with Transformed Hepatic Cells in Culture John M. Whiteley, John Galivan and Malgorzata Balinska Requires Authentication Unlicensed Licensed Download PDF	915
A Novel Technique for Producing Folate-Deficient Hepatica Cells Malgorzata Balinska, William Samsonoff and John Galivan Requires Authentication Unlicensed Licensed Download PDF	921
Methotrexate Metabolism in Acute Lymphoblastic Leukemia V. Michael Whitehead and David S. Rosenblatt Requires Authentication Unlicensed Licensed Download PDF	927
Altered Methotrexate Sensitivity in Human Leukemic K562 Amino Acid Transport Mutant Cells Kevin J. Scanlon, Rona Riegelhaupt, Michele Pallai, Holly Kisthard, Sharon Kassan and Samuel Waxman Requires Authentication Unlicensed Licensed Download PDF	933
Methotrexate and Methotrexate Polyglutamates in Erythrocytes After High-Dose Methotrexate Andreas Schalhorn, Hansjörg Sauer, Wolfgang Wilmanns and Gabriele Stupp-Poutot Requires Authentication Unlicensed Licensed Download PDF	941
Methotrexate Polyglutamates in Human Fibroblasts: Reversal of Antifolate Cytotoxicity David S. Rosenblatt and V. Michael Whitehead Requires Authentication Unlicensed Licensed Download PDF	947
Human Cells Resistant to Methotrexate: Cross Resistance and Collateral Sensitivity to the Nonclassical Antifolates Trimetrexate, Metoprine, Homofolic Acid and CB3717 Heyke Diddens, Dietrich Niethammer and Robert C. Jackson Requires Authentication Unlicensed Licensed Download PDF	953
Homology of Two Forms of Dihydrofolate Reductase in Human Leukaemic and L1210 Cells During Expression of Resistance to Methotrexate Philip Lamey, Nigel Harding and Jocelyn Dow Requires Authentication Unlicensed Licensed Download PDF	959
Adaptation of Folylpolyglutamates to Folate Deprivation in Mouse Hepatoma Cells D. G. Priest, M. T. Doig and M. Mangum Requires Authentication Unlicensed Licensed Download PDF	965
Utilization and Loss of Reduced Folates by Human Fibroblasts in Vitro Jack H. Hilton, Bernard A. Cooper, David S. Rosenblatt and Helena Lue-Shing Requires Authentication Unlicensed Licensed Download PDF	971
Factors Affecting Folate Polyglutamate Biosynthesis in Rat Liver S. Keating, D. G. Weir and J. M. Scott Requires Authentication Unlicensed Licensed Download PDF	977
Differential Binding of Folates but not Methotrexate (MTX) by Brush Border (BB) and Basal Lateral (BL) Membranes of Rat Renal Cortex Roberto Corrocher, R. G. Abramson, F. V. King, C. Schreiber and S. Waxman Requires Authentication Unlicensed Licensed Download PDF	983
Biosynthesis of Folate Derivatives in Ehrlich Ascites Carcinoma Cells Grown in Mice and in some Organs of the Host Ewa Sikora and Barbara Grzelakowska-Sztabert Requires Authentication Unlicensed Licensed Download PDF	989
Variability of Thymidylate Synthetase in Ehrlich Carcinoma Cells and its Role in Resistance to 5-Fluorodeoxyuridine Malgorzata Jastreboff, Barbara Kfdzierska and Wojciech Rode Requires Authentication Unlicensed Licensed Download PDF	995
One-Carbon Metabolism in Human Lymphocytes P. B. Rowe, E. McCairns, D. Sauer and G. Craig Requires Authentication Unlicensed Licensed Download PDF	1001
Possible Mechanisms of Folate Catabolism A. E. Pheasant, J. A. Blair, A. M. Saleh, A. E. Guest, P. A. Barford, R. Choolun and R. N. Allan Requires Authentication Unlicensed Licensed Download PDF	1007
The Intracellular Folate Pool: Studies of Kinetics and Functional Significance Stephen Steinberg, Susan Fonda, Caryl L. Campbell and Robert S. Hillman Requires Authentication Unlicensed Licensed Download PDF	1013
Intestinal Folate Transport. A pH-Dependent, Carrier- Mediated Process Williamson B. Strum and Hamid M. Said Requires Authentication Unlicensed Licensed Download PDF	1019
Effects of Folate Depletion on Growth and Survival of Human Cell Line K-562 in Culture David Watkins, Thomas E. Shapiro and Bernard A. Cooper Requires Authentication Unlicensed Licensed Download PDF	1025
Alterations in Folate Metabolism of the Rat Induced by Acute Ethanol Administration Kenneth E. McMartin and Timothy D. Collins Requires Authentication Unlicensed Licensed Download PDF	1031
Participation of Pterins in the Control of Lymphocyte Transformation and Lymphoblast Proliferation Irmgard Ζ¡eger, Ulrike Ham and Jürgen Berndt Requires Authentication Unlicensed Licensed Download PDF	1037
The Pterin Component of the Molybdenum Cofactor (Molybdopterin): Relationship to Urothione Jean L. Johnson, Bryan E. Hainline and Κ. V. Rajagopalan Requires Authentication Unlicensed Licensed Download PDF	1043
Report on Presented Papers C. J. Suckling and J. M. Scott Requires Authentication Unlicensed Licensed Download PDF	1049
Author Index Requires Authentication Unlicensed Licensed Download PDF	1057
Subject Index Requires Authentication Unlicensed Licensed Download PDF	1063
Backmatter Requires Authentication Unlicensed Licensed Download PDF	1072

Language: English
Publisher: De Gruyter
Edition: Reprint 2014
Pages
- Front matter: 34
- Main content: 1070
Illustrations
- Other: Zahlr. Abb.
Keywords: Pteridine; Folsäure

eBook

Published: February 6, 2015
ISBN: 9783111619453

Hardcover

Published: April 1, 1983
ISBN: 9783110085600